This systematic review and meta-analysis looked at how well antibiotic-impregnated cement works for treating diabetic foot osteomyelitis. The study combined data from eight small studies involving 82 patients who underwent 85 procedures. Researchers wanted to see if this local treatment could control infection and keep the limb while allowing patients to walk.
The analysis found that 85.2% of the procedures led to a weighted healing rate. However, the cement stayed in place in only 63.6% of cases. In 24.4% of cases, the cement had to be removed, and in 8.2% it was exchanged. These actions represent discontinuations of the original plan.
Safety concerns included minor amputation in 13.4% of cases and secondary surgery in 18.7% of cases. The study authors noted that serious adverse events were not reported, but the evidence comes from a limited number of studies. This is Level IV evidence, which means the findings are based on small, observational, or case series data rather than large randomized trials. Readers should understand that while this option fills a gap in infection control, it is not a guaranteed cure for every patient.