This systematic review and meta-analysis looked at adults who had endoscopic submucosal dissection to remove colorectal polyps. The researchers compared those who received prophylactic clipping with those who did not receive the clip. The study included 684 patients in total.
The main finding was that patients who received the clip had a reduced risk of clinically significant delayed bleeding. The risk dropped from 3.4 percent to 0.3 percent in the group that got the clip. The difference was statistically significant.
The study also checked for other complications like postprocedural perforation and postelectrocoagulation syndrome. There was no significant difference in the risk of these events between the two groups. The analysis did not find significant differences in subgroups based on lesion size or location.
This evidence supports adopting clipping as part of routine practice for these procedures. However, the study did not report specific adverse events or discontinuations. Readers should note that subgroup analyses by location and size were not significant.