Some people are born with weak immune systems because of genetic errors. These errors can stop white blood cells from fighting infections. Scientists now have a powerful new way to see exactly which genetic changes cause these problems. This helps doctors understand why some patients struggle with severe infections from birth.
Researchers used a special tool called CRISPR to test nearly 500 different genetic changes in human immune cells. They found that 470 of these changes had a real impact on how the cells function. Most importantly, they discovered 90 new mutations that completely stop the cells from developing. This means the immune system cannot form a proper defense against germs.
The results matched perfectly with existing medical databases that classify genetic changes as safe or dangerous. This confirms the tool is accurate and reliable. While the study did not report any safety issues or side effects, it focuses on understanding the science behind these genetic errors. This knowledge gives doctors a clearer picture of what goes wrong in patients with severe immune deficiencies.