Imagine taking a supplement every day for a month and wondering if it quietly changes your body. This small study asked exactly that about creatine hydrochloride. Eleven healthy adults took 750 mg of the supplement daily for 28 days at a single medical center. The goal was simply to see if their blood and urine tests showed any warning signs of trouble.
Most of the blood work stayed within normal limits. Lipid levels, blood cell counts, and kidney markers did not change in a way that mattered. However, fasting glucose did rise by about 8 mg/dL, and serum bicarbonate dropped slightly. Even with these small shifts, all values remained inside the safe ranges doctors use to judge health.
No one in the group stopped taking the pill because of side effects, and no serious problems occurred. But remember, this was a pilot study with only 11 people. It cannot tell us if the drug is safe for sick people, older adults, or for years of use. These results are just a first step, not a final answer.