This review looked at 14 types of dietary supplements for ulcerative colitis, including probiotics, selenium, and curcumin. It included 1,491 patients across 24 randomized trials, comparing supplements to standard treatment or a placebo.
The analysis found that probiotics and selenium showed advantages for reducing disease activity, while flaxseed extract and vitamin A helped lower Mayo scores. Several supplements, including probiotics and curcumin, were linked to better quality-of-life scores. Some also appeared to lower inflammation markers like C-reactive protein.
The review did not report on safety or side effects. A key reason to be cautious is that the included studies varied in quality, and the findings need validation from larger, more rigorous trials. The results show associations, not proven cause-and-effect.
Realistically, this suggests some supplements might help as add-ons for ulcerative colitis, but patients should discuss any supplement use with their doctor, as evidence is still early and incomplete.