Mode
Text Size
Log in / Sign up

Systematic review of orthognathic surgery outcomes in 6,482 patients with dentofacial deformitiesOrthognathic surgery improves jaw alignment and quality of life for thousands of patients

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider counseling patients on high neurosensory disturbance rates and 32.4% overall complication risk.

This systematic review and meta-analysis synthesized data from multiple studies to evaluate clinical outcomes, complications, and quality of life for orthognathic surgery in patients with dentofacial deformities. The pooled sample included 6,482 patients with a minimum follow-up duration of one year. The review focused on skeletal stability, complication rates, and functional recovery rather than specific surgical techniques or hospital settings.

mean ANB angle improvements for class III corrections were 6.8 degrees (95% CI: 6.2-7.4 degrees) and for class II corrections were 5.4 degrees (95% CI: 4.9-5.9 degrees). Skeletal stability was maintained in 87.3% of cases. Quality of life demonstrated substantial improvements with a standardized mean difference of -1.84 (95% CI: -2.12 to -1.56).

Safety data indicated an overall complication rate of 32.4% (95% CI: 28.7-36.1%). Neurosensory disturbances occurred in 52.8% of cases, with 92.6% recovering by 12 months. Permanent neurosensory alterations were observed in 3.4% of cases. Relapse greater than 2mm occurred in 18.7% of cases. The authors describe these adverse events as predominantly minor and self-limiting. Serious adverse events, discontinuations, and tolerability data were not reported.

The review did not identify specific funding sources or conflicts of interest. While the evidence supports the efficacy and safety profile of the procedure, the high rate of neurosensory disturbances requires careful patient counseling. The authors caution that complication rates are significant and that relapse is a common outcome. Practice relevance is limited to the need for realistic expectation setting regarding potential complications and recovery timelines.

Thousands of people struggle with jaw misalignment that affects their bite, speech, and daily comfort. A massive review of data from 6,482 patients offers a clear picture of what happens after orthognathic surgery. This procedure corrects the jaw bones to fix these problems. The analysis looked at how well the surgery worked, how often complications happened, and how patients felt afterward. The results show substantial improvements in quality of life for those who underwent the operation. The study tracked patients for at least one year to see how things held up over time. It found that the jaw position stayed stable in 87.3% of cases. This means the correction did not easily slide back to its original shape. Patients also saw significant changes in their ANB angle, a measurement of jaw alignment. For class III corrections, the angle improved by 6.8 degrees on average. For class II corrections, the improvement was 5.4 degrees. These numbers show the surgery effectively moves the jaw into a better position. Safety was a major part of the review. Complications occurred in 32.4% of cases. Most of these were minor and went away on their own. Numbness or tingling in the lips or chin happened in 52.8% of patients. This is a common side effect of moving the jaw. The good news is that 92.6% of these nerve issues recovered by the 12-month mark. Only 3.4% of patients had permanent nerve changes. About 18.7% of patients experienced a relapse where the jaw shifted more than 2 millimeters. This review confirms that orthognathic surgery is a reliable way to fix jaw deformities. It brings lasting benefits to patients while managing risks that are mostly temporary.

What this means for you:
Orthognathic surgery improves jaw alignment and quality of life for most patients, with most nerve issues resolving within a year.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
Orthognathic surgery is a definitive treatment for dentofacial deformities, yet comprehensive synthesis of clinical outcomes, complications, and quality of life impacts remains limited. This systematic review critically evaluates contemporary evidence on orthognathic surgery effectiveness and safety. A systematic search of PubMed/MEDLINE, Embase, Cochrane CENTRAL, Web of Science, and Scopus was conducted through December 2024. Studies reporting clinical outcomes, complications, or quality of life following orthognathic surgery in patients with dentofacial deformities were included. Quality assessment employed the Cochrane Risk of Bias tool and Newcastle-Ottawa Scale. Meta-analysis with random-effects models was performed where appropriate. Sixty-five studies encompassing 6,482 patients were included. Mean ANB angle improvements were 6.8° (95% CI: 6.2-7.4°) for class III and 5.4° (95% CI: 4.9-5.9°) for class II corrections, with 87.3% maintaining skeletal stability at ≥1-year follow-up. Overall complication rate was 32.4% (95% CI: 28.7-36.1%), predominantly minor and self-limiting. Neurosensory disturbances occurred in 52.8% of cases, with 92.6% recovering by 12 months and permanent alterations in 3.4%. Relapse (>2mm) occurred in 18.7% of cases. Quality of life demonstrated substantial improvements with standardized mean difference of −1.84 (95% CI: −2.12 to −1.56, p 
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.