Conservative O2 targets (88-92%) safe in PICU, cut respiratory support vs conventional targets
This open-label randomized controlled trial, conducted in a tertiary care pediatric intensive care unit between May 2023 and November 2024, compared conservative versus conventional oxygen saturation targets in critically ill children requiring respiratory support. Children aged 1 month to 15 years requiring invasive or noninvasive oxygen therapy were randomized to conservative (SpO₂ 88-92%) or conventional (SpO₂ 94-99%) targets, with FiO₂ titrated to maintain assigned ranges. The primary outcome was a composite of death and organ support at 30 days. A total of 178 children were randomized, with comparable baseline characteristics and illness severity between groups. The median composite outcome score was 8 (IQR 4-20.25) in the conservative group and 10 (IQR 5-20) in the conventional group, a non-significant difference (p=0.15). Key secondary outcomes showed the conservative group had a significantly shorter duration of respiratory support (4 days vs 6 days; p=0.003) and oxygen therapy (8 hours vs 100 hours; p<0.001). Mortality at 7 and 30 days, organ support days, length of PICU and hospital stay, and oxidative stress assessed by serum malondialdehyde levels at baseline and day 7 were similar between groups. The authors conclude that conservative oxygen saturation targets were safe and resulted in similar mortality and organ dysfunction, with reduced duration of respiratory support and oxygen therapy. They note that larger multicenter trials are needed to confirm these findings.
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Standardized formal resuscitation training likely reduces neonatal mortality in low- and middle-income countries compared to no training or basic training.
A Simple Training Program Is Saving Newborn Lives in Poor Countries
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