Researchers combined data from nine different studies to look at how growth hormone therapy affects eye structure in children with idiopathic short stature. The group examined measurements like corneal curvature, axial length, and intraocular pressure alongside refractive status. They found no significant association with corneal curvature, axial length, or intraocular pressure. However, there was a significant association found with refractive status. The data showed high variation between the included studies, which makes the overall picture unclear.
There were no reported adverse events, serious issues, or discontinuations related to the therapy in these reports. Despite the lack of clear safety signals, the high inconsistency in the data limits what can be concluded. The uncertainty around axial length and pressure measurements means current monitoring practices should not change based on this evidence alone.
Readers should understand that while a possible link to refractive changes exists, the evidence is too inconsistent to be definitive. These results are considered hypothesis-generating rather than proof of harm or benefit. Doctors should continue to follow standard care while awaiting more consistent data from future research.
