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MIH affects roughly one in six Spanish children, with prevalence varying widely by regionOne in Six Spanish Children Have Molar Incisor Hypomineralisation

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Key Takeaway
Recognize MIH as common in Spanish children, but interpret prevalence cautiously due to regional and methodological variation.

This meta-analysis synthesizes epidemiological data on molar-incisor hypomineralisation (MIH) among Spanish children and adolescents aged 6 to 18 years. The primary aim was to estimate the prevalence of MIH in this population and to explore methodological and geographical factors contributing to variability across studies.

The main finding is that approximately one in six Spanish children is affected by MIH. However, the authors report significant geographical variation in prevalence estimates and methodological heterogeneity among the included studies, which limits direct comparability and the precision of any single national estimate. No pooled effect size, confidence interval, or p-value was reported for the prevalence estimate.

The review does not report sample size, follow-up duration, or adverse events, as these are not applicable to a prevalence meta-analysis. The authors acknowledge that the heterogeneity and geographical variation are important limitations. They highlight the need for standardized diagnostic protocols and nationally representative epidemiological studies to improve comparability and support preventive oral health strategies.

In practice, these findings suggest that MIH is relatively common among Spanish children, but clinicians should interpret prevalence estimates with caution given the variability across regions and studies. The results underscore the importance of consistent diagnostic criteria and representative sampling in future research.

How this fits prior evidence

This meta-analysis provides a national prevalence estimate for MIH in Spanish children, which complements prior coverage of a treatment-related question in the same condition. The earlier finding that 4% articaine improves anaesthetic success rates compared to 2% lidocaine in children with MIH addressed clinical management, whereas this review addresses disease burden. Together, they extend the evidence base for MIH by quantifying how many children may be affected and by highlighting the need for standardized diagnostic protocols, which is consistent with the methodological concerns raised in the prior coverage.

Researchers looked at the prevalence of molar-incisor hypomineralisation, known as MIH, among children and adolescents in Spain. This condition affects the appearance and structure of the enamel on the permanent first molars and incisors. The study focused on a group of children and teenagers aged between 6 and 18 years old.

The findings show that approximately one in six Spanish children is affected by this condition. The researchers also noted that there is significant variation in how often the condition is found depending on the location and the methods used to diagnose it. Because of these differences, it can be hard to compare data from different regions.

Because of the high number of cases found, the study suggests that dental professionals need better, standardized ways to diagnose the condition. Having a consistent way to identify MIH can help improve oral health plans for children. This information helps experts understand how common the issue is across the country.

What this means for you:
About one in six Spanish children has a tooth condition called molar-incisor hypomineralisation.

Common questions

What is molar-incisor hypomineralisation?

Molar-incisor hypomineralisation, or MIH, is a condition that affects the enamel on the first permanent molars and incisors. It can affect the appearance and structure of these teeth. This study found that about one in six children in Spain is affected by this specific condition.

How common is this condition in children?

The study found that approximately one in six Spanish children and adolescents between the ages of 6 and 18 have molar-incisor hypomineralisation. This high prevalence suggests that it is a common issue for many children in that region.

Why do the results vary between different areas?

The study noted that there is significant geographical variation and differences in how the condition is measured. Because of these differences, experts recommend using more standardized diagnostic tools to get a clearer picture of how many children are affected.

Study Details

Study typeMeta analysis
EvidenceLevel 1
Follow-up216.0 mo
PublishedNov 2026
View Original Abstract ↓
AIM: To systematically evaluate the prevalence of molar-incisor hypomineralisation (MIH) among Spanish children and adolescents and to investigate methodological and geographical factors contributing to the variability of prevalence estimates. MATERIALS: A systematic review and meta-analysis was conducted according to the PRISMA 2020 guidelines and prospectively registered in PROSPERO (CRD420261411600). PubMed, Scopus, Embase, Ovid MEDLINE, CINAHL and grey literature sources were searched. Cross-sectional studies reporting MIH prevalence in Spanish children aged 6-18 years were included. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. Pooled prevalence estimates were calculated using random-effects logistic regression models. Subgroup analyses, meta-regression and sex-specific analyses were performed to explore sources of heterogeneity. CONCLUSION: Approximately one in six Spanish children is affected by MIH, placing Spain among the European countries with the highest reported prevalence. Significant geographical variation and methodological heterogeneity persist, highlighting the need for standardized diagnostic protocols and nationally representative epidemiological studies to improve comparability and support preventive oral health strategies.
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