Repeated red light therapy reduces axial length elongation in premyopic children over 24 months.
This randomized controlled trial enrolled 108 premyopic children with cycloplegia spherical equivalent refraction between -0.50 and +0.75 D. Participants underwent 24.0 months of follow-up to evaluate sustained efficacy and rebound effects of the therapy. The study was conducted in an unspecified setting.
The intervention involved repeated red light therapy administered two times per day for 3 min per session, with at least 4-hour interval. The RRLT group showed significantly smaller axial length elongation compared with controls, with absolute numbers of 0.26 mm versus 0.43 mm. Spherical equivalent refraction progression was also reduced in the RRLT group at -0.21 D compared with -0.66 D in controls. Both outcomes indicate a reduction in myopia-related changes during the study period.
Safety data regarding adverse events, serious adverse events, and discontinuations were not reported. Subfoveal choroidal thickness thinning was significantly less in the RRLT group at -2.44 µm compared with -44.12 µm in controls. Washout subgroup analysis indicated faster axial length elongation and more choroidal thinning after cessation. Limitations were not reported in the study documentation. No adverse events were documented in the provided text.
Practice relevance was not reported. Clinicians should note the rebound effects in the washout subgroup when considering long-term management strategies for premyopia. Further research is needed to confirm long-term safety. Current evidence does not support definitive practice changes.
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