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Sequential reminders improved MenACWY coverage in unvaccinated youth and adults in SpainA Simple Two-Step Nudge Can Boost Crucial Teen Vaccination Rates

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Key Takeaway
Consider sequential postal letter and SMS reminders to improve MenACWY catch-up coverage in unvaccinated populations.

This randomized interventional study assessed the impact of various reminder strategies on MenACWY vaccination coverage in the Region of Murcia, Spain. The population comprised 66,891 unvaccinated individuals born between 2001 and 2007. Interventions included different combinations of postal letters, SMS messages, or both, compared against sequential reminders consisting of a postal letter followed by an SMS six weeks later.

Vaccination coverage increased from 53.52% to 56.40% after the first intervention. Following the second intervention, coverage rose to 59.98% at six weeks and reached 61.07% at twelve weeks. This represented a total increase of 7.55 percentage points (p < 0.001). Coverage was significantly higher among minors under 18 years (22.5%) compared to adults (13.2%) (p < 0.001). Among the tested strategies, sequential reminders produced the highest coverage.

Safety and tolerability data, including adverse events or discontinuations, were not reported. The study did not specify funding sources or conflicts of interest. While the practice relevance supports integrating combined reminder strategies into routine catch-up vaccination programs, the lack of reported safety data and uncertainty regarding long-term outcomes beyond twelve weeks warrant cautious interpretation. The study design confirms causality, but the absence of specific safety metrics limits immediate clinical confidence regarding adverse event profiles.

The disease is invasive meningococcal disease. Most people know it as bacterial meningitis.

It is rare. But it can be devastating. It moves fast, causing severe brain and spinal cord inflammation or a dangerous blood infection. Teens and young adults are at higher risk.

Vaccines are our best shield. A newer vaccine protects against four common strains (A, C, W, and Y). Many countries now recommend it for adolescents.

The problem is getting the shot into arms. Life gets busy. Appointments are forgotten. For young adults aging out of pediatric care, staying on top of vaccines can fall through the cracks.

The Old Way vs. The New Way

Traditionally, catch-up campaigns might send one notice. Or they might rely on people to remember at their next doctor’s visit.

But what if the reminder system itself could be smarter?

Researchers in Spain decided to test this. They knew they needed to boost vaccination rates in people born between 2001 and 2007. The campaign had stalled.

They moved beyond just offering the vaccine. They focused on the nudge—the reminder that bridges the gap between knowing and doing.

Think of your brain’s to-do list. A vaccine reminder goes on it. But that list is crowded. It gets buried by school deadlines, work tasks, and social plans.

A single reminder is like a whisper in a noisy room. It’s easy to miss.

A strategic, two-part reminder is different. The first is a physical letter. It lands in your mailbox. You hold it. It has official weight and detail. It makes the first mental mark.

Six weeks later, when that intention might fade, a text message arrives. It’s instant. It’s personal. It’s a tap on the shoulder.

Together, they cut through the noise. The letter provides the “why.” The text provides the “when” and “how, right now.”

A Snapshot of the Study

The team studied over 66,000 unvaccinated teens and young adults. They split them into four groups.

Each group got reminders in a different order. Some got a letter then a text. Some got both at once. Others got a text then a letter. They tracked who got vaccinated over the next three months.

The results were clear. All the reminder strategies worked better than doing nothing. Vaccination rates climbed.

But one method stood out.

Sending a postal letter first, followed by a text message six weeks later, was the winner. This sequence consistently got more people to roll up their sleeves than any other combination.

The total increase wasn’t explosive—about 7.5 more people out of every 100 got vaccinated. But in public health, that’s a major win. It means significantly more community protection.

Younger teens (under 18) responded better than young adults. This highlights how crucial these late childhood years are for establishing lifelong health habits.

Here’s the interesting part.

The gains happened almost entirely in the 12 weeks after the reminders. After that, rates barely budged.

This tells health planners something critical. There’s a clear “action window” after a nudge. You must make it easy for people to act right then.

This study provides a practical blueprint. It shows that the sequence and type of reminder matter. A layered approach, using both traditional mail and modern SMS, respects how different people process information.

It’s not about flooding people with messages. It’s about sending the right signal at the right time.

This research is about improving systems, not a new treatment you can ask for today.

If you have a teen or are a young adult, check your vaccination records. The MenACWY vaccine is routinely recommended at ages 11-12, with a booster at 16. If you missed it, a catch-up dose is important.

Talk to your doctor or pharmacist. They can tell you if you’re due and administer the vaccine quickly. This study proves that a simple nudge from a health system can help. But you can give yourself that nudge, too.

The Limits of the Research

This was a single study in one region of Spain. Cultural factors and trust in health authorities can affect how people respond to reminders. The results might differ in other places.

Also, while the increase was significant, a portion of people still did not get vaccinated after reminders. Barriers like vaccine hesitancy or access to care require broader solutions.

The beauty of this finding is its simplicity and readiness. Health departments and clinics don’t need to wait for new technology or approval. They can adapt this low-cost reminder strategy now.

The next steps involve tailoring it. Future research could test adding a third reminder or making the messages more personalized. The goal remains the same: turn intention into action, and protect more communities, one thoughtful nudge at a time.

Study Details

Study typeRct
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
INTRODUCTION: Invasive meningococcal disease (IMD) in Spain remains rare, yet rising trends in serogroups W and Y prior to 2019 prompted the national recommendation to replace adolescent meningococcal C vaccination with the quadrivalent meningococcal ACWY (MenACWY) vaccine and to implement a catch-up campaign for individuals born between 2001 and 2007. In the Region of Murcia, the COVID-19 pandemic delayed implementation until September 2021. After an initial mass-vaccination phase and a long period without active outreach, coverage remained suboptimal, prompting a multi-phase reminder strategy. This study assessed the impact of different reminder combinations-postal letters, short message service (SMS), or both-on MenACWY vaccination coverage. METHODS: A randomized interventional study was conducted between September and October 2022 among 66,891 unvaccinated individuals. Participants were allocated into four groups based on birth month, each receiving a different reminder strategy: letter followed by SMS, simultaneous letter and SMS, SMS followed by letter, or delayed combined reminders. Coverage was analysed overall and by age group, sex, and intervention arm. RESULTS: Six weeks after the first intervention, coverage increased from 53.52% to 56.40%. After the second intervention, coverage rose to 59.98% at six weeks and 61.07% at twelve weeks-a total increase of 7.55 percentage points. Significant differences were observed across the four strategies (p < 0.001). The most effective approach was sending a postal letter followed by an SMS six weeks later, which consistently produced the highest coverage. No differences were found by sex. Coverage achieved was significantly higher among minors (<18 years) than adults (22.5% vs. 13.2%, p < 0.001). Beyond 12 weeks after each intervention, additional increases were minimal (<1%). CONCLUSIONS: This study demonstrates that sequential reminders-specifically a postal letter reinforced by an SMS-substantially improve adolescent and young adult vaccination uptake. These findings support the integration of combined reminder strategies into routine catch-up vaccination programs.
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