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Long peripheral catheters reduce infusion failure compared to short catheters in late preterm and term neonatesLong IVs Beat Short Tubes for Newborns Needing Medicine

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Key Takeaway
Note that long peripheral catheters are associated with lower infusion failure rates than short catheters in neonates.

This single-center retrospective cohort study included 197 eligible neonates with a gestational age ≥34 weeks and birth weight ≥1,500 g. The intervention involved long peripheral catheters (LPCs), compared against short peripheral catheters (SPCs). The primary outcome was infusion failure, defined as premature discontinuation of the index device due to occlusion or extravasation requiring reinsertion or unplanned removal before completion of therapy.

LPC use was associated with a lower subdistribution hazard of failure than SPC use, with a subdistribution hazard ratio of 0.46 (95% confidence interval: 0.23–0.89). In absolute numbers, infusion failure occurred in 12 of 58 LPCs (21%) versus 48 of 108 SPCs (44%). Additionally, failure incidence per 1,000 device-days was 62 for LPCs compared to 146 for SPCs.

Safety analysis noted that adverse events consisted of occlusion or extravasation leading to premature discontinuation. Serious adverse events were not reported, and tolerability was not reported. A key limitation is that thrombotic complications were not assessed. Funding or conflicts of interest were not reported. The study concludes that LPCs may be a more reliable option for completing short-term planned peripheral infusion therapy in selected neonatal populations.

A new study suggests a simple change could make IV therapy more reliable for newborns in the neonatal intensive care unit (NICU). Researchers found that using longer IV catheters instead of shorter ones led to fewer failures. That means fewer painful needle sticks and fewer delays in giving babies the fluids and medicines they need.

This matters because many late preterm and term babies need short-term IV therapy. They may need antibiotics, fluids, or nutrition through a vein for a few days. When an IV fails, staff must start over. That can be stressful for families and risky for fragile newborns. Short peripheral catheters are the traditional choice. But they can clog or leak, forcing an unplanned removal before treatment is done.

But here’s the twist: longer peripheral catheters are not new. They have been used more often in recent years. Yet it was unclear if they truly worked better for short-term use in newborns. This study compared the two types while accounting for a key detail. Sometimes doctors change a catheter on purpose for medical reasons. That is not a failure. The researchers treated those cases as competing events, so the results reflect true failure risk.

Think of a short IV like a narrow straw in a cup. If the straw gets kinked or clogged, you cannot deliver the drink. A longer IV is like a longer, sturdier straw that reaches deeper into the cup. It may resist kinks and keep the flow steady. In the body, a longer catheter can sit in a larger vein segment, which may lower the chance of blockage or leakage.

The study included 197 newborns born at 34 weeks or later and weighing at least 1,500 grams. All were getting their first venous access device. About one-third received a long peripheral catheter; the rest got a short one. The team followed each baby until the device was removed. They tracked whether the catheter failed early due to clogging or leaking, or whether it was changed on purpose for treatment reasons.

Excluding those intentional changes, failure was much less common with long catheters. About 21% of long catheters failed, compared with 44% of short ones. Put another way, there were about 62 failures per 1,000 device-days with long catheters, versus 146 per 1,000 with short ones. The statistical models, which account for competing risks, showed long catheters cut the hazard of failure roughly in half.

This does not mean every newborn should get a long catheter automatically.

The findings suggest long catheters may be a more reliable option for completing planned short-term therapy in selected neonates. In practice, that could mean fewer reinsertions and less discomfort. But the decision should be individualized. Clinicians will weigh factors like vein size, the type of fluid or medicine, and the expected duration of therapy.

The study has important limits. It was done at a single center and looked back at medical records. The sample size was modest, and the babies were mostly late preterm and term, not extremely premature. The researchers did not assess thrombotic complications, which can be a concern with longer devices. Future studies should evaluate safety outcomes and test these results in other hospitals.

What happens next? Larger, multi-center studies are needed to confirm these findings and to examine safety in more detail. Hospitals may also consider training and protocols to ensure long catheters are placed and maintained correctly. If the results hold, long peripheral catheters could become the preferred choice for short-term IV therapy in many newborns.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
IntroductionLong peripheral catheters (LPCs) are increasingly used as alternatives to short peripheral catheters (SPCs) in neonatal intensive care units, but their effectiveness for short-term infusion therapy in late preterm and term neonates remains uncertain. This study compared the risk of failure between LPCs and SPCs while accounting for intentional device changes as competing events.MethodsWe conducted a single-center retrospective cohort study between November 2019 and October 2020, including neonates with gestational age ≥34 weeks and birth weight ≥1,500 g who received either a LPC or a SPC as the first venous access device. The primary outcome was infusion failure, defined as premature discontinuation of the index device due to occlusion or extravasation requiring reinsertion or unplanned removal before completion of therapy. Intentional change to another catheter for therapeutic reasons was treated as a competing event. Subdistribution hazard ratios were estimated using Fine–Gray competing-risks regression, and incidence rate ratios per 1,000 device-days were calculated using Poisson regression; cause-specific Cox models were used as complementary analyses.ResultsOf 197 eligible neonates, 66 received LPCs and 131 received SPCs. Median gestational age (37 weeks in both groups) and birth weight (2,750 g vs 2,760 g) were similar. Median dwell time was 3 days in both groups. Excluding intentional changes, failure occurred in 12/58 LPCs (21%) and 48/108 SPCs (44%). The incidence of failure was 62 versus 146 events per 1,000 device-days in the LPC and SPC groups. In the Fine–Gray model, LPC use was associated with a lower subdistribution hazard of failure than SPC use (subdistribution hazard ratios: 0.46, 95% confidence interval: 0.23–0.89). Cause-specific Cox models showed a similar association (adjusted hazard ratio: 0.42, 95% confidence interval: 0.22–0.83).ConclusionIn late preterm and term neonates requiring short-term peripheral infusion therapy, LPCs were associated with a significantly lower risk of failure and lower failure incidence per device-day than SPCs, even when intentional device changes were considered as competing events. LPCs as a more reliable option for completing short-term planned peripheral infusion therapy in selected neonatal populations, with the caveat that thrombotic complications were not assessed and warrant evaluation in future studies.
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