CSTE and CDC develop surveillance case definition for MIS-C associated with SARS-CoV-2

The Council of State and Territorial Epidemiologists (CSTE) and Centers for Disease Control and Prevention (CDC) have developed a surveillance case definition for Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection. This definition was created for use in the United States to standardize reporting and monitoring of this condition. The publication describes the development of this definition but does not report on a specific study type, phase, population, sample size, or validation results.

No intervention, comparator, or clinical outcomes are reported, as this appears to be a methodological publication focused on establishing surveillance criteria rather than reporting clinical trial or observational study results. The document does not contain data on treatment effects, patient outcomes, or comparative effectiveness of different approaches to MIS-C management.

Safety and tolerability information, adverse events, and discontinuation rates are not reported, as this publication does not describe a therapeutic intervention. Key limitations include the absence of validation data, performance characteristics (sensitivity, specificity), and information about how this definition was developed or tested in clinical populations. The practice relevance is limited to public health surveillance; clinicians should consult clinical guidelines rather than relying solely on surveillance definitions for diagnosis and management decisions.