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Narrative review explores transcranial magnetic stimulation feasibility for chronic respiratory diseases

Narrative review explores transcranial magnetic stimulation feasibility for chronic respiratory dise…
Photo by National Cancer Institute / Unsplash
Key Takeaway
Note limited evidence for transcranial magnetic stimulation in chronic respiratory disorders due to constraints.

This publication is a narrative review focusing on patients with chronic respiratory disorders. It assesses the feasibility of transcranial magnetic stimulation as an adjunctive respiratory training approach. The scope includes physiological respiratory mechanisms and the neural origins of diaphragmatic dysfunction. The review does not report specific study settings or follow-up durations.

The authors synthesize arguments regarding the activation of the diaphragm and address comorbid anxiety and depression associated with respiratory impairment. They propose novel conceptual frameworks for respiratory impairment management based on existing literature. No specific sample sizes or statistical outcomes were reported in this review. Safety data regarding tolerability and discontinuations were not reported.

The authors acknowledge significant limitations in respiratory training efficacy. These issues stem from methodological constraints and poor patient adherence observed in the reviewed literature. There are also questions about long-term benefits that remain unresolved. Consequently, the evidence remains limited.

Clinical application requires caution due to the lack of reported safety data and adverse events. The evidence supports further investigation rather than immediate widespread implementation. Practitioners should recognize the preliminary nature of these findings when considering treatment options. Future research is needed to establish standardized protocols for clinical use. Adverse event rates were not reported in the source material.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Chronic respiratory disorders (CRDs) are the third most common cause of cancer- and cardiovascular disease-related mortalities. Non-pharmacological interventions for CRDs effectively slow disease progression, improve quality of life, ameliorate symptoms, and potentially extend survival. Pulmonary rehabilitation faces limitations in respiratory training efficacy owing to methodological constraints, poor patient adherence, and questions about long-term benefits. Transcranial magnetic stimulation (TMS) has been used to demonstrate the capacity of cortical excitability modulation to cause neuronal plasticity. For respiratory function, TMS exhibits dual diagnostic and therapeutic applications; it can identify neural origins of diaphragmatic dysfunction, directly stimulate pathways to activate the diaphragm, and address comorbid anxiety and depression through limbic cortical circuitry. This review outlines the physiological respiratory mechanisms and evaluates the current evidence for TMS interventions in respiratory dysfunction. Our objectives are to elucidate TMS mechanisms in CRDs, evaluate its feasibility as an adjunctive respiratory training approach, and propose novel conceptual frameworks for respiratory impairment management.
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