11 pipeline articles
Phase 4 study of evolocumab safety and tolerability in renal transplant recipients
Can a new cholesterol drug help kidney transplant patients without causing harm?
This Phase 4 study evaluated the safety and tolerability of evolocumab, a PCSK-9 inhibitor, in renal transplant recipients at three hospital…
A new cholesterol injection kept kidney transplant patients safe for over two years without serious side effects, offering a potential alter…
Dimethyl fumarate with slow titration improves treatment satisfaction and quality of life in Iranian MS patients
Oral Pill Beats Shots for MS Patients
A 12-month, multicenter, phase 4 observational study of 645 Iranian patients with relapsing-remitting multiple sclerosis initiating dimethyl…
An oral pill for multiple sclerosis improves sleep and mood while boosting patient satisfaction compared to monthly injections.
Oral polio vaccine and behavioral information versus no vaccine in adults over 50 years of age
Old Vaccine Might Help Stop COVID
This Phase 4 randomized trial evaluated the effect of oral polio vaccine plus behavioral information compared with no vaccine in 3,729 perso…
An old polio vaccine pill given to adults in Guinea-Bissau might protect older people from severe coronavirus illness and death.
Liposomal bupivacaine, nerve blocks compared to lidocaine for skin graft donor site pain in burn patients
What's the best way to ease pain after skin graft surgery for burn patients?
A two-phase study (RCT and prospective cohort) in 74 burn patients with <20% TBSA burns compared liposomal bupivacaine injection and preoper…
Burn patients with minor injuries face intense donor site pain after skin graft surgery, but doctors haven't yet reported which numbing meth…
Phase 4 trial compares pioglitazone versus dapagliflozin add-on in type 2 diabetes
Trial compares two diabetes drug combinations but results are not yet available
A phase 4 randomized controlled trial in South Korea enrolled 133 participants with type 2 diabetes inadequately controlled by DPP-4 inhibit…
A completed trial in South Korea compared two three-drug combinations for type 2 diabetes, but results on blood sugar control are not yet av…
Digital albuterol system feasibility studied in 333 asthma patients with suboptimal control
Can a smart inhaler help people with uncontrolled asthma breathe easier?
A phase 4, open-label, multicenter feasibility study randomized 333 participants aged 13+ with suboptimal asthma control to either the Albut…
A new smart inhaler system tested for 12 weeks to see if it helps people with uncontrolled asthma breathe easier, but results are not yet av…
Phase 4 trial compares LPV/r plus raltegravir versus LPV/r plus N(t)RTIs for HIV after first-line failure
Study compares two HIV treatment strategies after first-line therapy fails
A phase 4 randomized controlled trial enrolled 558 HIV-infected subjects who had virologically failed first-line NNRTI-based therapy. The st…
A completed Phase 4 trial compared two HIV treatment strategies after first-line therapy fails, but results for viral suppression and safety…
Phase 4 study evaluates nitroglycerin's effects on stroke volume in 21 AHF patients
Can a common heart drug help people with acute heart failure breathe easier?
A Phase 4 study enrolled 21 patients with acute heart failure to evaluate the effects of nitroglycerin on stroke volume. The study aimed to …
Nitroglycerin may help acute heart failure patients pump more blood and flush out fluid to ease breathing in the critical early hours of tre…
Atorvastatin evaluated for dyslipidemia in children with steroid-sensitive nephrotic syndrome
Can a common cholesterol drug protect children's hearts and kidneys from a hidden danger?
A quasi-experimental study of 100 children aged 8-18 years with steroid-sensitive nephrotic syndrome and dyslipidemia evaluated the effectiv…
A common cholesterol drug called atorvastatin may help children with kidney disease reach safer heart and blood fat levels when diet alone i…
Vedolizumab with Adalimumab or Ustekinumab Studied for Crohn's Endoscopic Response
Can New Drug Combinations Offer Hope for Crohn's Disease Sufferers?
Phase 4 trial investigates vedolizumab with adalimumab or ustekinumab in Crohn's. Primary endpoint: endoscopic response at 26 weeks.
Adults with moderate to severe Crohn's disease may find new relief by combining vedolizumab with adalimumab or ustekinumab before continuing…
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use
Could Ketamine Be the Key to Easing Pain and Healing Minds After Surgery?
This Phase 4 trial investigates ketamine's efficacy in reducing postoperative pain and opioid use in orthopedic trauma patients. Primary out…
A new trial tests if giving ketamine during orthopedic surgery reduces pain, opioid needs, and symptoms of depression and PTSD compared to s…