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Formaldehyde exposure in pathology laboratories shows strong association with nasopharyngeal cancer and genotoxicityLaboratory Workers Face Risks From Formaldehyde Exposure in Pathology Rooms

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Key Takeaway
Note the strong association between formaldehyde and nasopharyngeal cancer and the high prevalence of exceeding 0.3 ppm.

This systematic scoping review and qualitative study evaluates formaldehyde (FA) exposure and associated risk perceptions among healthcare workers in pathology and anatomy laboratories. The synthesis identifies a strong association between formaldehyde and nasopharyngeal cancer, as well as low-dose genotoxicity. However, the evidence regarding myeloid leukemia is noted as inconsistent.

Data from the review indicate significant environmental risks in laboratory settings. Specifically, 83.3% of evaluations documented concentrations exceeding 0.3 ppm. In autopsy rooms, peak exposure levels reached up to 8.4 ppm. These findings highlight the prevalence of high-concentration environments for laboratory staff.

Qualitative findings regarding risk perception indicate that healthcare workers often have lower awareness of chemical hazards compared to biological risks. Notably, non-prevention-specialist physicians exhibited lower risk perception and lower PPE adherence than non-physician staff. The authors suggest these findings highlight the need for optimized preventive strategies, updated regulatory frameworks, and targeted awareness campaigns to address both technical and subjective barriers to safety.

How this fits prior evidence

This review confirms a strong association between formaldehyde and nasopharyngeal cancer. It addresses a gap in understanding the risk perception of healthcare workers in pathology settings. While the review notes inconsistent findings regarding myeloid leukemia, it provides context for the dual oncogenic and tumor-suppressing roles of PKC isoforms in myeloid and lymphoid leukemia by highlighting the specific environmental risks of formaldehyde in laboratory settings.

A review of laboratory settings found that formaldehyde is often present at high levels in pathology and anatomy labs. In some cases, concentrations were found to exceed 0.3 ppm in over 83 percent of evaluations. In autopsy rooms, peak exposure levels were recorded as high as 8.4 ppm.

Research shows a strong link between formaldehyde and nasopharyngeal cancer. While the evidence for myeloid leukemia is less consistent, the chemical is known to have genotoxicity at low doses. These findings highlight the importance of safety measures in environments where these chemicals are used regularly.

The study also looked at how workers perceive these risks. Some physicians showed a lower awareness of chemical hazards compared to biological risks. This difference in perception can affect how often personal protective equipment is used. Because of these findings, experts suggest that better training and updated safety rules could help protect staff from chemical exposure.

What this means for you:
High formaldehyde levels in some labs are linked to nasopharyngeal cancer, highlighting a need for better safety.

Common questions

What health risks are linked to formaldehyde exposure?

Research shows a strong association between formaldehyde and nasopharyngeal cancer. There is also evidence of low-dose genotoxicity. While the findings regarding myeloid leukemia are inconsistent, the chemical is a known risk in laboratory environments where it is used in pathology and anatomy work.

How much formaldehyde is present in pathology labs?

In the settings studied, 83.3% of evaluations showed concentrations exceeding 0.3 ppm. In specific areas like autopsy rooms, peak exposure levels were recorded as high as 8.4 ppm. These levels indicate a significant presence of the chemical in some work areas.

Do healthcare workers recognize the risks of chemical exposure?

The study found that some professionals had a lower awareness of chemical hazards compared to biological risks. Specifically, non-prevention-specialist physicians showed lower risk perception and lower rates of using personal protective equipment compared to non-physician staff.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
PurposeOccupational exposure to formaldehyde (FA) in the healthcare sector remains a significant concern due to its carcinogenic and genotoxic potential, particularly among professionals working in pathology and anatomy laboratories. The objective of this study was to analyze the scientific evidence, regulatory frameworks, and chemical risk perceptions associated with formaldehyde (FA) exposure in healthcare settings.MethodsAn integrated methodological design was employed. First, a systematic scoping review of scientific and grey literature was conducted to synthesize health effects and regulatory frameworks regarding FA. Second, an exploratory qualitative descriptive and interpretative study was carried out through two focus groups, comprising physicians and non-physician healthcare professionals, to explore subjective risk perceptions.ResultsThe scoping review confirmed formaldehyde’s strong association with nasopharyngeal cancer and low-dose genotoxicity, while findings regarding myeloid leukemia remain inconsistent. Hospital exposure studies revealed that 83.3% of pathology laboratory evaluations documented ambient concentrations exceeding 0.3 ppm, with peak exposures in autopsy rooms reaching up to 8.4 ppm. The qualitative focus groups demonstrated a lower awareness of chemical hazards compared to biological risks, driven by the latent, non-visible nature of chemical exposure. Clear disparities across professional profiles were identified: non-prevention-specialist physicians exhibited lower risk perception and PPE adherence than non-physician healthcare staff. Key operational barriers included inadequate formal training, institutional productivity pressures prioritizing patient flow, and social stigma surrounding safety culture compliance.ConclusionThese findings underscore the need for optimized preventive strategies, regulatory updates, and targeted awareness campaigns to safeguard worker health. This comprehensive approach highlights the importance of addressing both technical and subjective factors to effectively reduce FA exposure in healthcare settings.
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