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Home-based pulmonary rehabilitation reduces anxiety and depression in advanced lung cancer patientsHome-based exercise program with nurse support may help reduce anxiety and depression in advanced lung cancer patients

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Key Takeaway
Consider home-based pulmonary rehabilitation for psychological distress in advanced lung cancer, noting 63.5% adherence.

A randomized controlled trial evaluated a nurse-supported hybrid home-based pulmonary rehabilitation program (PRP) in 104 patients with stage III-IV lung cancer. The intervention consisted of home-based aerobic, resistance, and breathing exercises three times weekly after an initial supervised session, compared to a control group (specific components not described). Outcomes were assessed at baseline, week 4, and week 8.

At week 8, the intervention group showed significantly greater reductions in anxiety (β = -1.72, 95% CI [-3.04, -0.40], p = .01) and depression (β = -1.21, 95% CI [-2.35, -0.07], p = .04) compared to the control group. Quality of life and functional performance were maintained in the intervention group but declined in the control group, though the magnitude of change was not quantified and absolute numbers were not reported.

No exercise-related serious adverse events occurred, and program adherence was 63.5%. Key limitations include unspecified control group components, unquantified changes in quality of life and functional performance, and unknown long-term effects beyond the 8-week study period. The study used intention-to-treat analysis.

For practice, this home-based PRP shows potential for reducing psychological distress in advanced lung cancer patients with a favorable safety profile. However, clinicians should note the moderate adherence rate and lack of long-term data when considering implementation.

Researchers studied whether a home-based exercise program could help people with advanced lung cancer. The program included aerobic, resistance, and breathing exercises done three times weekly at home, with initial guidance and nurse support. They compared 104 patients who either did this program or received standard care without the specific exercises.

After 8 weeks, the group doing the exercises reported significantly less anxiety and depression than the comparison group. Their quality of life and ability to perform daily activities also stayed stable, while these measures declined in the comparison group. No serious exercise-related health problems occurred, and about two-thirds of participants stuck with the program.

It's important to know this was a relatively small study that lasted only 8 weeks, so we don't know if the benefits continue long-term. The study also didn't describe exactly what care the comparison group received. While these results are promising, they suggest that structured home exercise with support might help manage emotional distress in advanced lung cancer, alongside standard medical care.

What this means for you:
A small study found home exercise with nurse support may reduce anxiety and depression in advanced lung cancer over 8 weeks.

Study Details

Study typeRct
Sample sizen = 104
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
PURPOSE: This study aimed to evaluate the effectiveness and safety of a nurse-supported hybrid home-based pulmonary rehabilitation program (PRP) in reducing psychological distress and preserving quality of life (QoL) and functional performance in patients with advanced lung cancer. METHODS: A randomized controlled trial was conducted with 104 patients with stage III-IV lung cancer randomly assigned to an intervention group (n = 52) or a control group (n = 52). The intervention group received home-based aerobic, resistance, and breathing exercises three times weekly after an initial supervised session. Anxiety and depression were primary outcomes, while QoL and functional performance were secondary outcomes. Outcomes were assessed at baseline, week 4, and week 8 and analyzed using generalized estimating equations under an intention-to-treat approach. RESULTS: Groups were comparable at baseline. At week 8, the intervention group showed significantly greater reductions in anxiety (β = -1.72, 95% CI [-3.04, -0.40], p = .01) and depression (β = -1.21, 95% CI [-2.35, -0.07], p = .04) compared with the control group. QoL and functional performance were maintained in the intervention group but declined in the control group. Program adherence was 63.5%, and no exercise-related serious adverse events occurred, including among participants with bone metastases. CONCLUSIONS: A nurse-supported hybrid PRP is an effective intervention for reducing psychological distress and preserving functional status in patients with advanced lung cancer. The observed safety profile further supports its clinical applicability, including for high-risk populations. TRIAL REGISTRATION: Clinical trial ID: NCT05279521; First patient enrolled: April 14, 2022.
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