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Ultrasound-guided venous puncture reduces composite access site complications to 0.6% in atrial fibrillation ablationUltrasound guidance reduces serious complications during heart procedure access

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Key Takeaway
Consider ultrasound-guided venous puncture to reduce access site complications and unintended arterial punctures.

This multicentre randomized controlled trial enrolled 986 patients undergoing catheter ablation for atrial fibrillation or left atrial tachycardia. The study compared ultrasound-guided venous puncture to conventional venous puncture guided by palpation. The trial was stopped for efficacy after the first interim analysis.

The primary outcome was a composite of arteriovenous fistula, false aneurysm, or access site bleeding requiring intervention or leading to prolonged hospitalization within 30 days. The intervention group showed 3 (0.6%) events compared to 16 (3.3%) in the control group (3/496 vs 16/490). The risk ratio was 0.19 (95% confidence interval 0.05-0.63; P =.002).

Secondary outcomes included significant reductions in unintended arterial punctures (2% vs 16%; P <.0001) and failed venous access attempts requiring crossover (0.2% vs 8.2%; P <.0001). The study was open-label.

While ultrasound-guided access significantly reduced vascular complications, the open-label nature of the study is a limitation. The results suggest ultrasound guidance may improve safety during the initial access phase of catheter ablation procedures.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap in procedural safety for atrial fibrillation management. While previous coverage noted that pulsed-field ablation shows shorter ablation times and lower phrenic nerve palsy than cryoballoon ablation, this study focuses on the safety of the initial venous access. It provides evidence that ultrasound-guided puncture reduces complications compared to palpation-guided methods.

When doctors perform procedures to treat irregular heartbeats like atrial fibrillation, they must first gain access to the veins. This initial step is critical because a mistake can lead to serious issues like bleeding or the formation of abnormal blood vessels. This study looked at how using an ultrasound to guide that first step impacts patient safety.

Researchers followed nearly 1,000 patients to compare ultrasound-guided vein entry against the standard method of feeling for the vein by hand. The results showed that using ultrasound significantly lowered the risk of serious complications at the entry site. Specifically, the group using ultrasound had much lower rates of bleeding and other issues that would require extra medical intervention or longer hospital stays.

Beyond the main safety goals, the ultrasound group had far fewer failed attempts to find a vein and fewer accidental punctures of nearby arteries. While the study was an open-label trial, the data suggests that ultrasound guidance provides a safer way to begin these important heart procedures.

What this means for you:
Ultrasound-guided vein access significantly reduces serious complications and accidental artery punctures during heart procedures.

Common questions

How does ultrasound-guided access improve safety?

Using ultrasound to guide the needle helps doctors see the vein clearly. In this study of 986 patients, this method significantly reduced the risk of serious complications like bleeding or the formation of abnormal blood vessels. It also led to much lower rates of accidental artery punctures compared to the standard method.

What specific complications were reduced by using ultrasound?

The study found that ultrasound-guided access reduced the risk of a composite of complications, including arteriovenous fistulas, false aneurysms, and bleeding that requires extra treatment. The rate of these issues was 0.6% for those using ultrasound compared to 3.3% for those using the standard method.

Does ultrasound make it easier to find a vein?

Yes, the data shows that ultrasound-guided access makes the initial step more reliable. The study found that the number of failed vein access attempts requiring a switch in method was only 0.2% for the ultrasound group, compared to 8.2% for the group using the standard method.

Study Details

Study typeRct
EvidenceLevel 2
PublishedSep 2026
View Original Abstract ↓
BACKGROUND AND AIMS: Vascular access site complications are the most common procedure-related adverse event of atrial fibrillation catheter ablation. Whether ultrasound-guided femoral venous puncture reduces these vascular access complications remains uncertain. METHODS: In this investigator-initiated, multicentre, open-label, superiority trial, patients undergoing atrial fibrillation or left atrial tachycardia catheter ablation were randomized to an ultrasound-guided venous puncture strategy (intervention group) or to a conventional venous puncture group guided by palpation (control group). The composite primary outcome was the occurrence of venous access site complications until 30 days after the procedure, defined as arteriovenous fistula, false aneurysm, or access site bleeding requiring intervention or leading to prolonged hospitalization. Secondary endpoints included procedure duration, puncture duration, procedure-related stroke/transient ischaemic attack within 30 days, number of unintended arterial punctures, and number of failed venous access attempts, as well as hospital stay duration. RESULTS: In six centres, 986 patients were randomized. A total of 496 patients were assigned to the ultrasound-guided puncture group, and 490 patients to the conventional puncture group. The trial was stopped for efficacy, following the first interim analysis after enrolment of half of the planned patients. The composite primary outcome occurred in 3 patients (0.6%) in the intervention group and 16 patients (3.3%) in the control group (risk ratio 0.19; 95% confidence interval 0.05-0.63; P = .002). Additionally, ultrasound-guided venous puncture significantly reduced the rate of an unintended arterial puncture (2% vs 16%, P < .0001) and the rate of unsuccessful venous access attempts requiring crossover to the other group (0.2% vs 8.2%, P < .0001). CONCLUSIONS: Ultrasound-guided venous access for atrial fibrillation ablation procedures significantly reduced vascular access site complications. ULYSSES CLINICALTRIALS.GOV NUMBER: NCT06403527.
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