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161Tb-PSMA radioligand therapy achieves 83.9% disease control rate in metastatic castration-resistant prostate cancerRadioligand Therapy Shows Promise for Metastatic Prostate Cancer

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Key Takeaway
Note that 161Tb-PSMA radioligand therapy shows an 83.9% disease control rate in mCRPC despite significant heterogeneity.

This meta-analysis evaluates the efficacy and safety of 161Tb-PSMA radioligand therapy (RLT) for patients with metastatic castration-resistant prostate cancer (mCRPC). The analysis synthesized data from 6 studies involving a total of 80 patients to determine primary and secondary outcomes.

The meta-analysis reported a disease control rate (DCR) of 83.9% (95% CI: 76.0-92.0%) and an objective response rate (ORR) of 50.2% (95% CI: 27.0-74.0%). Regarding safety, the pooled adverse event rate was 41%, with high grade events occurring in 18% of those cases. The authors characterized the overall safety profile as acceptable.

Several limitations impact the certainty of these results, including a small sample size and significant heterogeneity in ORR (I2 = 81%). The authors noted that larger-scale, comparative trials across multiple centers over longer observation periods are required to confirm these findings. While the data suggest 161Tb-PSMA RLT is a potential therapeutic option for mCRPC, the current evidence is limited by the small number of included patients and high heterogeneity.

Researchers looked at data from 80 patients with metastatic castration-resistant prostate cancer to see how they responded to a specific treatment called 161Tb-PSMA radioligand therapy. This analysis combined results from six different studies to get a clearer picture of the treatment's impact.

The findings showed that about 83.9% of patients experienced disease control. Additionally, more than half of the patients, specifically 50.2%, showed an objective response to the treatment. While many side effects were reported, only 18% of those events were considered high grade, suggesting the treatment has a manageable safety profile.

It is important to note that these results come from a small group of patients across only six studies. Because the data comes from a small sample and shows significant differences in how patients responded, more large-scale trials are needed. This finding suggests the therapy is a potential option for this type of cancer, but it is not yet a standard replacement for current treatments.

What this means for you:
Radioligand therapy showed high disease control rates in a small group of patients with metastatic prostate cancer.

Common questions

What is the success rate of this treatment?

The analysis showed a disease control rate of 83.9% among the 80 patients studied. Additionally, the objective response rate was found to be 50.2%. These numbers suggest that many patients saw their cancer progress slow down or shrink during the study period.

Is this treatment safe for prostate cancer patients?

The treatment showed an acceptable safety profile in the study. While there were 124 total adverse events, only 18% of those were high grade. You should talk to your doctor to see if this specific therapy is appropriate for your personal health needs.

How much evidence is there for this treatment?

The current evidence is limited because the study only included 80 patients from six different sources. Because of the small sample size and variations in results, larger trials are needed to confirm these findings before it can be widely adopted as a standard treatment.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedAug 2026
View Original Abstract ↓
IntroductionProstate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) using Terbium-161 [161Tb]-labeled compounds has recently been investigated in patients with metastatic castration-resistant prostate cancer (mCRPC). We performed a systematic review and meta-analysis to evaluate the efficacy and safety of [161Tb]Tb-PSMA RLT in this clinical setting.MethodsWe conducted a comprehensive literature search across PubMed/MEDLINE, Embase, and the Cochrane databases to retrieve published articles on the efficacy and safety of [161Tb]Tb-PSMA RLT in mCRPC. Studies reporting the use of [161Tb]Tb-PSMA RLT in mCRPC patients were eligible for inclusion. Pooled estimates of disease control rate (DCR), objective response rate (ORR), and adverse event rate were calculated using a random-effects model. Statistical heterogeneity was assessed using the I2 statistic.ResultsSix studies published between 2024 and 2026, including 80 mCRPC patients treated with 291 cycles of [161Tb]Tb-PSMA RLT, were included. Most patients had pretreated disease and had previously received PSMA-targeted radionuclide therapy. The pooled DCR was 83.9% (95% confidence interval [CI]: 76.0–92.0%) with no significant heterogeneity (I2 = 0%). The pooled ORR was 50.2% (95% CI: 27.0–74.0%), although significant heterogeneity was observed (I2 = 81%). Across all studies, 124 adverse events were reported, corresponding to a pooled adverse event rate of 41%, but high grade were only 18.ConclusionCurrent evidence suggests that [161Tb]Tb-PSMA RLT is a promising therapeutic option for patients with mCRPC, demonstrating encouraging disease control and an acceptable safety profile. Nevertheless, defining its precise role requires larger-scale, comparative trials conducted across multiple centers over longer observation periods.
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