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Self-administered acupressure and hypnosis show no group-level effects on blood pressure in hypertensionAcupressure and hypnosis show mixed results for high blood pressure

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Key Takeaway
Note that while acupressure and hypnosis are highly feasible, they showed no significant group-level effect on blood pressure.

This meta-analysis synthesized data from N-of-1 trials to evaluate the efficacy of self-administered acupressure and hypnosis as interventions for patients with grade 1 or 2 hypertension. The analysis focused on primary outcomes of systolic and diastolic blood pressure, along with secondary measures including stress levels, vitality, well-being, feasibility, and safety.

The meta-analysis found no overall effects on cardiovascular outcomes at the group level. However, individual variability was noted: 2/17 patients showed reductions with both acupressure and hypnosis, while 1/17 patient showed reduction with acupressure only compared to routine care. Stress levels were higher during the run-in period (mean 43.6 [SD 18.9]) compared to subsequent blocks. The interventions demonstrated high feasibility with adherence exceeding 90%.

Limitations include a small sample size of 17 and a lack of significant group effects, leading to low certainty for clinical recommendations. While the interventions were well-tolerated with only mild and rare adverse events reported during acupressure, further studies are required to identify specific conditions where these therapies might provide clinical benefit. Clinical application is currently limited by the lack of consistent evidence for blood pressure reduction at a population level.

How this fits prior evidence

This meta-analysis addresses a gap in non-pharmacological interventions for hypertension. It contrasts with findings that acupuncture may reduce systolic blood pressure by about 6.6 mmHg in adults with hypertension, as this study found no group-level changes using acupressure and hypnosis. While both methods are feasible for patients to self-administer, the results do not confirm a consistent reduction in blood pressure across the studied population.

Managing high blood pressure is a constant challenge for many people. Some patients have explored alternative methods like acupressure or hypnosis to help manage their numbers. A review of 17 individual cases looked at whether these techniques actually made a difference compared to standard care.

The study found that most people did not see a change in their blood pressure when using these methods. However, a few specific individuals did see lower readings when they used acupressure and hypnosis together or just acupressure alone. While the treatment was easy for people to do on their own and was well tolerated, it did not show a consistent effect for everyone.

Because the study looked at such a small group of people, the results are not definitive. We still need more research to understand who might benefit from these techniques. If you are looking for ways to manage your blood pressure, talk with your doctor about what works best for your specific health needs.

What this means for you:
Acupressure and hypnosis were easy to do but did not consistently lower blood pressure for the group studied.

Common questions

Can acupressure or hypnosis lower my blood pressure?

The study showed mixed results. While most people in the group did not see a change in their blood pressure, 2 out of 17 patients saw reductions when using both acupressure and hypnosis. Another patient saw a reduction with only acupressure. Because the sample size was small, these results are not certain for everyone.

Is it safe to try acupressure or hypnosis for hypertension?

The methods were found to be very easy for people to do themselves and were well tolerated by those involved. Only mild and rare side effects were reported, mostly during the acupressure sessions. No serious safety issues were reported in the study.

How did patients feel while using these treatments?

Patients reported high levels of participation with over 90% adherence to the program. While stress levels were higher during a one-week starting period, they stayed similar between different treatment periods. You should speak with your doctor about how these methods might fit into your personal care plan.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedAug 2026
View Original Abstract ↓
BackgroundAcupressure and hypnosis are used by patients with arterial hypertension despite limited evidence supporting their efficacy. The aim of this N-of-1 series was to evaluate feasibility, individual patient responses to both interventions, to inform personalized treatment decisions, and to assess overall effects of interventions.MethodsIn a series of N-of-1 trials, we compared self-administered acupressure plus routine care (RC), hypnosis plus RC, and RC alone in patients with grade 1 or 2 hypertension. After a one-week run-in period with RC only, patients entered a six-week intervention phase consisting of two blocks with periods of acupressure, hypnosis and RC only, each followed by washout periods, administered in randomized order. Outcomes included systolic and diastolic blood pressure and pulse rate, which were measured by patients according to a standardized protocol. Patients recorded cardiovascular parameters, stress levels, vitality, and well-being using visual analogue scales, and documented feasibility and safety data in a study diary. The primary analysis of continuous outcomes was descriptive and conducted at the individual trial level. Secondary analyses included meta-analysis across all N-of-1 trials and outcomes. Overall group effects were analyzed using mixed-effects ANCOVA models.ResultsAltogether 17 patients (59% female, mean age 54.4 [SD 7.6]) were included in this study. Feasibility of interventions was high, as reflected by an adherence rate exceeding 90%. Two patients showed reductions in systolic and diastolic blood pressure with both acupressure and hypnosis, and one patient with acupressure only, compared to RC. In the meta-analysis, no overall effects of acupressure or hypnosis on cardiovascular outcomes were observed. Overall, stress levels were higher during the run-in period (mean 43.6 [SD 18.9]) compared to the subsequent blocks and were similar between treatment periods. All other outcomes remained unchanged. Reported side effects were mild, rare, and occurred mainly during acupressure.ConclusionThis series of N-of-1 RCTs was feasible for self-administered acupressure and hypnosis for hypertension. No relevant changes in outcome parameters, including blood pressure, were observed at the group level, although selected patients showed individual changes. Further studies are needed to identify the treatment as well as individual conditions under which clinical benefits can be expected.Clinical trial registrationDeutsches Register für klinische Studien (DRKS) 00034937, https://drks.de/search/de/trial/DRKS00034937/details.
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