Complete hydatidiform mole with normal fetus in twin gestation after embryo transfer: case reportTwin Pregnancy Complication Linked to Gestational Trophoblastic Disease

This publication is a case report and literature review, not a large-scale clinical trial. It describes a single case of a complete hydatidiform mole coexisting with a normal fetus in a twin gestation that occurred after embryo transfer. The report's scope is to present the diagnostic workup and clinical implications of this rare condition.

The diagnosis was confirmed through serial serum β-human chorionic gonadotropin (β-hCG) measurements, ultrasonographic features, chromosomal analysis, and histopathological findings. The main result is the confirmation of the diagnosis in this one case. No effect sizes, p-values, or confidence intervals are reported, as this is a descriptive case report.

The authors note that the case highlights the risk of persistent gestational trophoblastic disease (PTD) when a complete hydatidiform mole coexists with a normal fetus in a twin gestation after embryo transfer. This is a clinically relevant consideration for clinicians managing such pregnancies.

Limitations include the small sample size, as this is a single case report. The follow-up duration, adverse events, and other safety outcomes were not reported. Given the nature of the evidence, findings should be interpreted cautiously and not generalized to broader populations.

In practice, this report underscores the importance of careful monitoring in twin gestations involving a complete hydatidiform mole, particularly regarding the risk of persistent trophoblastic disease. However, further evidence from larger studies is needed to inform definitive clinical recommendations.