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Two-stage hysteroscopic myomectomy in diffuse uterine leiomyomatosis led to natural conception and full-term delivery in a 29-year-old nulliparous woman.

Two-stage hysteroscopic myomectomy in diffuse uterine leiomyomatosis led to natural conception and f…
Photo by Faustina Okeke / Unsplash
Key Takeaway
Consider two-stage hysteroscopic myomectomy for diffuse uterine leiomyomatosis, noting evidence is limited to a single case report.

This study is a case report and literature review focusing on a 29-year-old nulliparous woman diagnosed with diffuse uterine leiomyomatosis. The patient underwent a two-stage hysteroscopic myomectomy as the intervention. No comparator group was included in this specific case description.

The primary outcomes assessed were pregnancy and delivery. After the procedure, the patient conceived naturally. Subsequently, she delivered a healthy full-term infant. No specific numerical data, p-values, or confidence intervals were reported for these outcomes as the study design does not support statistical analysis.

Safety and tolerability data were not reported in the provided input. The study notes that diffuse uterine leiomyomatosis is frequently misdiagnosed, which may impact patient selection and surgical planning. No serious adverse events or discontinuations were documented in the input data.

Key limitations include the single-patient design, lack of a control group, and absence of long-term follow-up data. Because this is a case report, the results cannot establish causality or predict outcomes for other patients. The practice relevance is limited to suggesting that this approach may be considered in similar cases, but clinicians should remain cautious and seek further evidence before adopting this strategy broadly.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Diffuse uterine leiomyomatosis is frequently misdiagnosed, highlighting the need to improve awareness and understanding of this rare condition. We report a case of a 29-year-old nulliparous woman presenting with menorrhagia who was diagnosed with diffuse uterine leiomyomatosis and underwent a two-stage hysteroscopic myomectomy. She subsequently conceived naturally and delivered a healthy full-term infant. In addition, we review the existing literature on diffuse uterine leiomyomatosis to enhance its diagnosis and management.
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