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VATS and hormonal therapy for diaphragmatic endometriosis in a 42-year-old woman with hepatic herniationCan surgery alone fix rare chest pain caused by endometriosis, or is a team approach needed?

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Key Takeaway
Consider coordinated multidisciplinary management for diaphragmatic endometriosis, as surgical repair alone may be insufficient.

This case report and review of literature focuses on a 42-year-old woman presenting with diaphragmatic endometriosis, hepatic herniation, and catamenial pneumothorax. The patient had a long history of cyclical thoracic pain associated with these rare manifestations of extrapelvic endometriosis. Diagnostic complexity and the progressive nature of the disease were noted as significant challenges in this setting.

The patient received video-assisted thoracoscopic surgery (VATS) with diaphragmatic reconstruction, followed by a subsequent VATS procedure involving pleurectomy and pleural abrasion. Hormonal therapy was also administered as part of the management strategy. The primary outcome of symptom control showed partial improvement, while long-term disease control remained a secondary goal that required ongoing attention.

Safety considerations included the recurrence or persistence of catamenial pneumothorax, which was listed as an adverse event. The case underscores that surgical repair alone may be insufficient in cases with significant thoracic involvement. Limitations of the evidence include the single-case nature of the report and the inherent diagnostic difficulties associated with this rare condition.

The practice relevance emphasizes the importance of early multidisciplinary collaboration between gynecologic and thoracic specialists. Coordinated management is essential to improve long-term disease control and address the severe complications that may arise from diaphragmatic rupture or herniation. Clinicians should recognize that extrapelvic endometriosis requires a tailored, collaborative approach rather than isolated intervention.

Imagine waking up with chest pain that comes and goes with your period. For a 42-year-old woman, this was not just a bad case of heartburn; it was a rare condition called diaphragmatic endometriosis. In this specific case, the tissue had grown on her diaphragm and even pushed into her liver, causing a dangerous herniation. She faced severe cyclical thoracic pain that made daily life difficult.

To manage this, she underwent video-assisted thoracoscopic surgery to repair the diaphragm, followed by further procedures to remove the lining of her chest cavity. She also took hormonal therapy to keep the tissue in check. The surgery provided partial symptom control, but the disease remained a challenge. This story shows that even with skilled surgery, the progressive nature of this condition means repair alone may not be enough.

The main takeaway is that early collaboration between gynecologic and thoracic specialists is vital. Because this condition is rare and often underrecognized, it can lead to severe complications like diaphragmatic rupture. A coordinated multidisciplinary management approach is essential to improve long-term disease control. Without this team effort, patients might face ongoing pain and risk further complications.

What this means for you:
Surgery alone may not be enough for rare chest pain from endometriosis; a team of specialists is essential for long-term control.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Diaphragmatic endometriosis is a rare and often underrecognized manifestation of extrapelvic endometriosis that may lead to severe complications such as diaphragmatic rupture or herniation. We report the case of a 42-year-old woman with a long history of cyclical thoracic pain who was finally diagnosed with right-sided diaphragmatic endometriosis, complicated by a large diaphragmatic defect and hepatic herniation. For more than two decades, her symptoms were misattributed to musculoskeletal causes, resulting in delayed diagnosis. Imaging revealed a right diaphragmatic defect with protrusion of the liver into the thoracic cavity, and video-assisted thoracoscopic surgery (VATS) confirmed the presence of ectopic endometrial glands as well as stroma positive for CD10 and estrogen/progesterone receptors. Surgical repair with diaphragmatic reconstruction was performed. However, the postoperative course was complicated by catamenial pneumothorax, requiring a second VATS procedure with pleurectomy and pleural abrasion Subsequent hormonal therapy resulted in partial symptom control. This case highlights the diagnostic complexity and progressive nature of diaphragmatic endometriosis and underscores the importance of early multidisciplinary collaboration between gynecologic and thoracic specialists. It further demonstrates that surgical repair alone may be insufficient in cases with thoracic involvement and that coordinated multidisciplinary management is essential to improve long-term disease control.
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