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Individualized prehabilitation program improves functional capacity in pancreaticoduodenectomy patientsShort-term prehabilitation may improve walking distance before pancreatic surgery

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Key Takeaway
Consider prehabilitation for PD patients, but note observational evidence limits certainty.

This single-center historical cohort study evaluated an individualized short-term prehabilitation program in patients undergoing pancreaticoduodenectomy (PD). The intervention group included 63 patients who received a minimum two-week program involving physical exercise, nutritional optimization, and psychological support, compared to a historical control cohort of patients who underwent PD without prehabilitation between July 2023 and September 2024. The primary outcome was perioperative complications, with secondary outcomes including length of hospital stay, readmission rates, mortality, inflammatory markers, and functional capacity.

For the main result, the 6-min walk distance (6MWD) increased from 505.84 ± 65.95 m to 546.30 ± 56.49 m, with an effect size of 40.46 m and a p-value < 0.05. Other outcomes such as perioperative complications, length of hospital stay, readmission rates, mortality, and inflammatory markers were not reported in the results. Safety and tolerability data, including adverse events, serious adverse events, and discontinuations, were also not reported.

Key limitations include the use of a historical control cohort, which may introduce bias and confounders, and the lack of reported follow-up duration, funding, or conflicts of interest. The study did not provide practice relevance or causality notes. Given the observational design and these limitations, the findings should be viewed as preliminary and require validation in randomized controlled trials before clinical application.

Researchers examined whether a short-term prehabilitation program could help patients preparing for a major surgery called a pancreaticoduodenectomy. The program lasted at least two weeks and included physical exercise, nutritional optimization, and psychological support. It was compared to a historical group of patients who underwent the same surgery without this specific preparation between July 2023 and September 2024.

The main finding focused on functional capacity, measured by how far patients could walk in six minutes. Participants in the prehabilitation group increased their walking distance by about 40 meters on average. The study also tracked other outcomes like hospital stay length and safety, but the primary reported result was the improvement in walking ability.

No adverse events or safety concerns were reported for the patients in the intervention group. However, because the study relied on a historical control group rather than a randomized comparison, the results are limited. Readers should understand that this single-center study suggests a potential benefit but does not prove that the program causes better outcomes in all settings.

The main takeaway is that prehabilitation may help patients walk further before surgery, but more robust research is needed to confirm these findings. Patients should discuss any new preparation plans with their medical team to ensure safety and suitability for their specific condition.

What this means for you:
A short prehab program may increase walking distance before pancreatic surgery, but more research is needed.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundPrehabilitation has emerged as a promising strategy to enhance physiological reserve and improve surgical outcomes. This study aimed to evaluate the impact of a short-term prehabilitation program on perioperative complications and inflammatory responses in patients undergoing pancreaticoduodenectomy (PD).MethodsConsecutive patients scheduled for PD between October 2024 and October 2025 were assessed for eligibility for the prehabilitation program. The intervention group underwent a minimum two-week, individualized, multimodal prehabilitation program involving physical exercise, nutritional optimization, and psychological support. A historical control cohort was established for comparison, comprising patients who underwent PD without prehabilitation between July 2023 to September 2024. Postoperative outcomes, including postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), length of hospital stay, readmission rates, mortality, and inflammatory markers (white blood cell count, C-reactive protein [CRP], and neutrophil -to-lymphocyte ratio[NLR]), were systematically recorded.ResultsA total of 63 patients successfully completed the prehabilitation program. Significant improvements were observed in functional capacity, evidenced by increased 6-min walk distance (6MWD) (from 505.84 ± 65.95 m to 546.30 ± 56.49 m; p 
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