GATT reduces IOP in normal-tension glaucoma patients over 24 months

This single-center retrospective case series investigated the effects of gonioscopy-assisted transluminal trabeculotomy (GATT) in a population of 9 patients with normal-tension glaucoma, comprising 12 eyes. Follow-up assessments were conducted on postoperative day 1, week 1, and months 1, 3, 6, 12, 18, and 24. No comparator group was reported for this analysis.

The primary outcome measured changes in intraocular pressure (IOP) and medication burden. At 24 months, the mean IOP decreased from 17.33 ± 3.53 mmHg to 13.33 ± 2.35 mmHg. The mean reduction was 4.00 ± 2.86 mmHg, with a 95% CI of 2.18–5.82 and a t-value of 4.844. The p-value was not reported. Secondary outcomes included complete and qualified success, postoperative events, and additional interventions or reoperations, though specific data for these were not detailed in the provided results.

Safety and tolerability data were not reported; adverse events, serious adverse events, discontinuations, and general tolerability were not documented. The study limitations include its retrospective case series design, single-center setting, and small sample size of 9 patients and 12 eyes. Funding or conflicts of interest were not reported. Because the study design does not distinguish association from causation and lacks a control group, the observed IOP reduction should be interpreted with caution before altering standard practice.