Review proposes biomarker-informed precision exercise anti-aging framework for older adults using technology-assisted physical activity

This narrative review addresses the application of technology-assisted physical activity, such as wearable sensors and tele-exercise platforms, within the context of healthy aging for older adults. The scope of the article centers on synthesizing a conceptual framework rather than presenting data from a specific primary trial or systematic analysis. Consequently, no specific sample size, setting, or follow-up duration is provided in the source material.

The authors synthesize arguments regarding the utility of individualized interventions and adherence strategies. Furthermore, the review highlights the relevance of biological aging biomarkers, including epigenetic clocks, senescence-associated secretory phenotype (SASP) markers, and organ-specific plasma proteomics, as potential targets for monitoring intervention effects. The text suggests these technologies could facilitate a precision approach to exercise prescription.

The review acknowledges that detailed safety data, such as adverse events or tolerability, were not reported. Similarly, specific primary outcomes and quantitative results were not included in the provided evidence. The authors note that the current evidence base relies on a proposed framework rather than established clinical trial data.

Practice relevance is framed cautiously, as the source proposes a biomarker-informed precision exercise anti-aging framework to support healthy aging. Clinicians should interpret these suggestions as conceptual guidance rather than evidence-based recommendations derived from randomized trials or large observational cohorts with defined effect sizes.