Mode
Text Size
Log in / Sign up

rTMS for Anxiety in Women Undergoing Elective Surgery: A Randomized ProtocolNew Brain Stimulation May Calm Surgery Anxiety Without Pills

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note that this is a study protocol; results are pending and clinical application is not yet supported.

This is a study protocol for a single-center, randomized controlled study conducted at the Affiliated Hospital of Jiaxing University. The planned population includes 252 female patients scheduled for elective surgery under general anesthesia. The intervention is active repetitive transcranial magnetic stimulation (rTMS) compared to sham rTMS.

The primary outcome is the change in anxiety score from baseline to 3 days post-operation. Secondary outcomes include anxiety scores, occurrence of postoperative delirium (POD), pain scores, frailty scores, and sleep quality scores. Follow-up is limited to 3 days post-operation.

Safety data such as adverse events, serious adverse events, discontinuations, and tolerability are not reported in this protocol. Limitations are not yet available as this is a protocol. Funding and conflicts of interest are not reported.

The practice relevance is expected to offer a successful non-pharmacological treatment approach for clinical practice, but this is speculative until results are available. Clinicians should await the completed study before considering rTMS for perioperative anxiety.

A New Way to Find Calm

Imagine you are about to have surgery. Your heart races, your palms sweat, and your mind won’t stop worrying. This feeling is very common. It is called perioperative anxiety. It happens before, during, and right after an operation.

For many people, this worry can make recovery harder. Doctors often give medicine to help, but what if there was a way to calm the brain without using drugs?

A new study is looking at a gentle, non-invasive treatment. It uses magnetic pulses to help relax the brain. This could be a new option for women facing surgery.

Perioperative anxiety is a widespread issue. It affects millions of patients every year. When anxiety is high, recovery can be slower. Pain can feel worse. Sleep is often disrupted.

Women are more likely to experience this type of anxiety than men. This is due to hormonal changes and higher emotional sensitivity. Current treatments often rely on medication. While drugs can help, they sometimes cause side effects like drowsiness or nausea.

There is a clear need for non-drug options. Patients want safe, effective ways to manage stress. This study aims to fill that gap.

The Old Way vs. The New Way

Traditionally, anxiety before surgery is treated with sedative pills. These drugs can make you feel sleepy or groggy. They help, but they are not perfect for everyone.

But here’s the twist. Doctors are now looking at the brain itself. They are asking: Can we change how the brain processes fear?

The new approach uses a tool called repetitive transcranial magnetic stimulation, or rTMS. It does not require surgery or medication. Instead, it uses a magnetic coil placed near the head. This coil sends gentle pulses to specific brain areas.

Think of the brain like a complex electrical grid. Sometimes, certain parts of the grid become overactive. This can trigger feelings of fear and worry.

rTMS works like a reset button for that grid.

A magnetic coil is held near the scalp. It sends a magnetic pulse through the skull. This pulse gently stimulates nerve cells in the brain. It helps to calm the overactive areas.

The process is painless. You might feel a tapping sensation on your head. There is no need for anesthesia. You can go home right after the session.

This study focuses on a specific brain region linked to anxiety. By targeting this area, rTMS may help lower stress levels before surgery.

Researchers at the Affiliated Hospital of Jiaxing University are leading this study. They plan to enroll 252 women who are scheduled for elective surgery.

Participants will be randomly assigned to one of two groups. One group will receive active rTMS. The other group will receive a sham treatment. This means they will get the same setup, but the machine will not deliver a real magnetic pulse.

The study will measure anxiety levels before and after surgery. It will also track pain, sleep quality, and recovery speed.

This study is a protocol. That means the researchers have outlined their plan, but the trial has not yet started. No results are available yet.

The main goal is to see if rTMS lowers anxiety scores three days after surgery. Secondary goals include checking for postoperative delirium, pain levels, and sleep quality.

If successful, this could show that rTMS is a helpful tool. It could offer a drug-free way to manage surgery stress.

This doesn’t mean this treatment is available yet.

Experts in anesthesia and psychology are watching this study closely. Non-drug treatments for anxiety are a hot topic in medicine.

If rTMS works, it could change how we prepare patients for surgery. It might reduce the need for sedative medications. It could also improve overall recovery.

However, experts caution that more research is needed. This is just one study. Larger trials will be required to confirm the results.

If you are a woman facing surgery, this research is promising. It suggests that new, non-drug options are being explored.

But it is important to stay realistic. This study is still in the planning phase. The treatment is not yet available in most hospitals.

If you have surgery anxiety, talk to your doctor. Ask about all your options. This might include therapy, relaxation techniques, or medication. There is no one-size-fits-all solution.

This study has some important limitations. First, it is a single-center study. This means it only takes place at one hospital. Results may not apply to everyone.

Second, the study is still a protocol. The actual data has not been collected yet. We cannot know if rTMS will work until the trial is done.

Third, the study focuses only on women. While this is important for understanding gender differences, it means the results may not apply to men.

The next step is to run the trial. Researchers will enroll patients and collect data. This process can take months or even years.

If the results are positive, they will publish them in a medical journal. Then, other scientists will review the findings.

If rTMS proves safe and effective, it could eventually become a standard treatment. But that will take time. Medical approvals are slow and careful.

For now, this study represents a hopeful step forward. It shows that medicine is always looking for better ways to care for patients.

Study Details

Study typeRct
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
IntroductionPerioperative anxiety is a widespread psychological issue among patients undergoing surgery and often has a significant impact on patient outcomes. Due to physiological and psychological characteristics such as hormonal fluctuations and higher emotional sensitivity, female patients generally have a higher incidence of perioperative anxiety compared to male patients. This investigation aims to examine the repetitive transcranial magnetic stimulation (rTMS) effects on perioperative anxiety in female patients.MethodsThis single-center, randomized, regulated investigation will be performed at the Affiliated Hospital of Jiaxing University. The investigation plans to enroll 252 female individuals scheduled for elective surgery under general anesthesia, who will be classified in a random manner to active rTMS or sham rTMS. The primary outcome is the change in anxiety score from baseline to 3 days post-operation. Secondary outcome measures include anxiety scores, occurrence of postoperative delirium (POD), pain scores, frailty scores, and sleep quality scores. Intention-to-treat and per-protocol populations were employed to conduct analyses.DiscussionThis research aims to estimate the influence of rTMS on perioperative anxiety in female patients. It is expected to offer a successful non-pharmacological treatment approach for clinical practice, alleviate anxiety symptoms in female patients during the perioperative period, and enhance the safety of surgical procedure and the quality of post-operative recovery for patients.Clinical trial registrationhttps://www.chictr.org.cn/index.html, identifier ChiCTR2500097991.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.