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Meta-analysis identifies prevalence and risk factors for postextubation dysphagia in ICU patientsOne third of ICU patients face swallowing difficulties

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Key Takeaway
Note that factors such as advanced age, high APACHE II scores, and prolonged intubation are associated with increased risk.

This meta-analysis synthesized data from 7,219 patients in the intensive care unit to evaluate the prevalence of postextubation dysphagia and identify associated risk factors. The analysis focused on patients undergoing orotracheal intubation.

The pooled prevalence of postextubation dysphagia was 35% (95% CI: 25–46). The authors identified several factors associated with an increased risk of the condition. Age was positively associated with risk, specifically for patients aged 65 years (OR = 2.72) and 70 years (OR = 2.34). Higher APACHE II scores also showed an association, particularly for scores 15 points or greater (OR = 4.69). Other identified risk factors included arrhythmia (OR = 3.30), neurological disorders (OR = 3.77), and emergency admission (OR = 2.30).

Duration of tracheal intubation and gastric tube retention were also linked to increased risk. For every hour of intubation, the risk increased (OR = 1.03), as did every day of intubation (OR = 1.13). Specifically, intubation lasting 72 hours or more was associated with an increased risk (OR = 8.15), and durations of 7 days or more showed an increased risk (OR = 2.06). Gastric tube retention was associated with increased risk (OR = 6.59), particularly when retention lasted 72 hours or more (OR = 3.43).

Clinicians may use these identified risk factors to assist in the early identification of high-risk individuals to implement targeted preventive measures. The study reports associations rather than causal relationships.

Waking up in the ICU is often a traumatic experience, especially if you needed a breathing tube to survive. For many, the struggle does not end when the tube comes out. A large analysis of over 7,000 patients shows that about 35% of people who undergo tracheal intubation (the use of a tube in the windpipe) develop postextubation dysphagia, which is a medical term for difficulty swallowing.

Several factors can make this swallowing problem more likely. Older age is a significant factor, particularly for those 65 and older. The study also found that having certain medical issues, like neurological disorders or heart rhythm problems (arrhythmia), increases the risk. The severity of the initial illness, measured by the APACHE II score, also plays a role.

How long a patient stays on the breathing tube matters, too. The risk climbs significantly for those who are intubated for 72 hours or longer. Other factors, such as having a gastric tube for more than 72 hours or arriving at the hospital through an emergency admission, are also linked to higher risks.

While these findings show clear links between certain conditions and swallowing issues, they show associations rather than direct causes. Recognizing these high-risk patterns could help ICU staff identify vulnerable patients early and start preventive care sooner.

What this means for you:
About 35% of ICU patients face swallowing issues after breathing tube removal, with higher risks for older adults.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
BackgroundEvidence suggests that 41% of ICU patients acquired postextubation dysphagia, substantially increasing the risk of aspiration and malnutrition. Studies on its prevalence and risk factors showed considerable variation. Our study aims to summarize the overall prevalence and identify risk factors for postextubation dysphagia in ICU patients undergoing orotracheal intubation.MethodsWe searched PubMed, Embase, Web of Science, Cochrane Library, CINAHL, Medline, China National Knowledge Infrastructure, Wanfang, SinoMed, and Technology Journal Database for studies on postextubation dysphagia from inception to July 5, 2025. Two researchers independently conducted the literature screening, quality assessment, and extracted data. Meta-analysis was performed using Stata software 18.0 and Review Manager software 5.3.ResultsTwenty-five studies were included, encompassing a total of 7,219 patients. The meta-analysis revealed that the overall prevalence of postextubation dysphagia was 35% (95% CI: 25–46). Age (OR = 1.03), age ≥ 65 years (OR = 2.72), age ≥ 70 years (OR = 2.34), Acute Physiology and Chronic Health Evaluation II (APACHE II) score (OR = 1.29), APACHE II score ≥ 15 points (OR = 4.69), arrhythmia (OR = 3.30), neurological disorders (OR = 3.77), tracheal intubation duration in hours (OR = 1.03), tracheal intubation duration in days (OR = 1.13), tracheal intubation duration ≥72 h (OR = 8.15), tracheal intubation duration ≥7 days (OR = 2.06), gastric tube retention (OR = 6.59), and gastric tube retention duration ≥72 h (OR = 3.43), emergency admission (OR = 2.30) were risk factors for postextubation dysphagia.ConclusionThe incidence of PED in ICU patients is relatively high, which is influenced by various factors. Based on the identified risk factors, clinical staff can early identify high-risk individuals and implement targeted preventive measures to avoid postextubation dysphagia.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD420251090144.
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