Tumor-associated neutrophils regulate PDAC progression via TGF-β and CXCR2 pathways
Can stopping white blood cells help stop pancreatic cancer from growing?
This systematic review examined tumor-associated neutrophils (TANs) in patients with pancreatic ductal adenocarcinoma (PDAC). The analysis d…
White blood cells that shield pancreatic cancer from treatment can be reprogrammed to fight the disease instead of fueling its growth.
Risk models for ICI-associated myocarditis occurrence and severity in patients receiving immune checkpoint inhibitors
Can blood tests and heart signals predict dangerous heart inflammation from cancer drugs?
This retrospective unmatched case-control study evaluated baseline biomarkers and combined signatures in 196 patients receiving immune check…
A mix of blood tests and heart rhythm checks can predict dangerous heart inflammation from cancer drugs with better accuracy than blood work…
Federated model adaptation improves radiation pneumonitis prediction in lung cancer patients receiving immunotherapy.
Can we predict lung inflammation risk in patients getting immunotherapy?
This cohort study evaluated a federated radiomics model for predicting radiation pneumonitis in 610 lung cancer patients treated with defini…
A new model adapts to predict lung swelling risks for cancer patients receiving both radiation and immunotherapy, fixing errors in older too…
Baseline inflammation patterns in severe asthma patients receiving biologic therapy
Severe asthma patients with neutrophilic patterns had lower lung function and more sleep apnea
This retrospective observational cohort study analyzed 103 patients with severe asthma treated with biologic agents. Results described basel…
Severe asthma patients with neutrophilic patterns had lower lung function and more sleep apnea than those with other inflammation types.
Stapokibart shows nasal symptom reduction in pediatric seasonal allergic rhinitis case series
Could a new drug help teens breathe easier during allergy season?
A retrospective case series of 20 pediatric patients with moderate-to-severe seasonal allergic rhinitis found that all patients demonstrated…
Twenty young patients with moderate-to-severe seasonal allergic rhinitis took stapokibart for one month. Every single person saw a significa…
Acupuncture plus sphenopalatine ganglion needling shows higher response rate than loratadine for allergic rhinitis
Acupuncture combined with targeted needling may improve allergy symptoms better than standard medication
A 260-patient RCT in persistent moderate-to-severe allergic rhinitis found combination acupuncture and sphenopalatine ganglion needling had …
Combining acupuncture with targeted needling helped more hay fever patients find relief than standard allergy medication alone.
Narrative review examines SBRT dose effects on tumor immune microenvironment for ICI resistance
Review explores how radiation dose affects immune response to cancer immunotherapy
A narrative review synthesizes evidence on using stereotactic body radiation therapy to engineer the tumor immune microenvironment and overc…
Moderate radiation doses may unlock better immune responses to cancer treatments, while very high single doses could weaken the body's natur…
Systematic review finds moderate to substantial concordance among fungal sIgE detection kits for asthma
Review finds variation in tests for fungal allergy in asthma patients
A systematic review of 16 human studies evaluating 32 commercial fungal sIgE detection kits found moderate to substantial concordance with t…
Asthma fungal allergy tests often give different results because commercial kits use different methods and cut-off points, making it hard to…
Chemotherapy in HGSOC patients modulates NK cell receptors and ligands, observational study finds
Chemotherapy linked to immune system changes in ovarian cancer patients
An observational cohort study of 107 HGSOC patients and 50 healthy controls found chemotherapy was associated with modulation of NK cell rec…
Chemotherapy in ovarian cancer may restore natural killer cell markers to healthy levels and boost proteins that help immune cells fight tum…
IFN-I signature correlates with alloimmunization transcriptomic programs in SLE patients
Could a common lupus signal reveal who's at risk for transfusion complications?
An observational cohort analysis of 150 SLE patients from three RNA-seq cohorts found a significant positive correlation between Type I inte…
A high Type I interferon signal in lupus patients strongly predicts genetic markers linked to dangerous immune reactions to blood transfusio…
Lysine lactylation links metabolism to neuroinflammation via chromatin and protein modification
Review explores how a metabolic process may influence brain inflammation
A systematic review synthesizes emerging evidence that lysine lactylation (Kla) couples glycolytic state to chromatin remodeling and protein…
A metabolic process adding lactate to proteins may signal how brain cells respond to inflammation and stress in injury or disease.
Systematic review links immune cell metabolic remodeling to outcomes in liver transplant recipients
Could immune cell energy shifts hold the key to better liver transplant survival?
A systematic review synthesizes evidence on immunometabolic remodeling in liver transplant recipients. It reports that dynamic adaptive chan…
Immune cell energy shifts after liver transplants determine rejection, injury, and tolerance, improving long-term survival, a new analysis f…