IFN-I signature correlates with alloimmunization transcriptomic programs in SLE patients
Could a common lupus signal reveal who's at risk for transfusion complications?
An observational cohort analysis of 150 SLE patients from three RNA-seq cohorts found a significant positive correlation between Type I inte…
A high Type I interferon signal in lupus patients strongly predicts genetic markers linked to dangerous immune reactions to blood transfusio…
Lysine lactylation links metabolism to neuroinflammation via chromatin and protein modification
Review explores how a metabolic process may influence brain inflammation
A systematic review synthesizes emerging evidence that lysine lactylation (Kla) couples glycolytic state to chromatin remodeling and protein…
A metabolic process adding lactate to proteins may signal how brain cells respond to inflammation and stress in injury or disease.
Systematic review links immune cell metabolic remodeling to outcomes in liver transplant recipients
Could immune cell energy shifts hold the key to better liver transplant survival?
A systematic review synthesizes evidence on immunometabolic remodeling in liver transplant recipients.
Immune cell energy shifts after liver transplants determine rejection, injury, and tolerance, improving long-term survival, a new analysis f…
Phase 1 trial finds inhaled JAK1 inhibitor londamocitinib reduces Feno in mild asthma
Can a new inhaled asthma drug calm lung inflammation? Early trial shows promise
This first-in-human, phase 1 randomized controlled trial in 85 healthy volunteers and 18 participants with mild asthma found inhaled londamo…
A new inhaled asthma drug cut a key lung inflammation marker by half in early human testing, showing promise for calming the quiet battle in…
Single-cell and spatial technologies reveal UC pathogenesis insights but face sample size and phenotype heterogeneity limits
New tech maps ulcerative colitis cells, but small study groups limit what we know for sure yet
This systematic review evaluated single cell RNA sequencing, spatial transcriptomic, and proteomic technologies in adult ulcerative colitis …
New technology maps exactly which cells drive ulcerative colitis inflammation, helping explain why some patients respond to medicine while o…
FOXA transcription factors modulate epithelial integrity and inflammation in allergic asthma models
Review explores how FOXA proteins may influence asthma and allergic airway disease
A systematic review examines the role of FOXA transcription factors in allergic airway disease.
In healthy lungs, FOXA proteins keep airways stable, but allergic reactions shift these levels to worsen inflammation and airway changes.
Oral deucrictibant reduced hereditary angioedema attack rates versus placebo in a phase 2 trial
Can a daily pill prevent painful swelling attacks for people with hereditary angioedema?
A phase 2 randomized trial in 34 adults with hereditary angioedema types 1 or 2 found that daily oral deucrictibant (20 mg or 40 mg) signifi…
A daily pill reduced painful hereditary angioedema attacks by 80% in adults taking it for 12 weeks, offering a new preventive option for thi…
Oral deucrictibant reduces hereditary angioedema attack severity in phase 2 crossover trial
Oral drug reduces hereditary angioedema attack severity in phase 2 trial
In a phase 2 randomized, double-blind, placebo-controlled crossover trial of 62 adults with hereditary angioedema, oral deucrictibant (10 mg…
A new oral drug reduced the severity of hereditary angioedema attacks compared to placebo, offering a convenient treatment option for painfu…
Comparative review of eight national food-based dietary guidelines shows convergence in scientific rigor and communication
How do countries tell people to eat? A look at eight national food guides
A narrative review comparing Food-Based Dietary Guidelines from eight countries found all adopted periodic revisions and strengthened alignm…
Eight countries are updating food guides with simpler visuals and cultural tips, but sustainability advice varies wildly between them.
Review proposes four-axis bone-muscle crosstalk framework for steroid-induced femoral head osteonecrosis
What's really happening in steroid-related hip bone death? A new theory connects bone and muscle
A systematic review proposes a theoretical four-axis pathophysiological framework for bone-muscle crosstalk in steroid-induced osteonecrosis…
A new theory suggests steroid-induced hip bone collapse stems from a breakdown in vital communication between bone and muscle tissue.
ACIP recommends RSV vaccination for adults 60 years and older in the United States
Should adults over 60 get the RSV vaccine? New recommendations say yes
The Advisory Committee on Immunization Practices (ACIP) issued a recommendation report for RSV vaccination in adults aged 60 years and older…
Adults 60 and older now have a clear official suggestion to get the RSV vaccine because the virus poses a significant health risk to this ag…
Bivalent COVID-19 vaccine effectiveness assessed in immunocompetent adults across nine states
Do the updated COVID-19 vaccines keep people out of the emergency room?
An observational study of immunocompetent adults in the VISION Network assessed the effectiveness of updated bivalent COVID-19 vaccines in p…
Updated COVID-19 vaccines aim to keep healthy adults out of the emergency room and hospital, but real-world results are still waiting to be …