Opioid receptor agonist-antagonists may improve analgesia and safety when co-administered with full mu-opioid agonists
New Framework Suggests Safer Ways to Manage Opioid Pain
This narrative review synthesizes preclinical and clinical evidence regarding the role of opioid receptor agonist-antagonists in multimodal …
Combining specific opioid receptor agonists and antagonists may improve pain relief while reducing common side effects like nausea and respi…
Transforaminal epidural steroid injections provide superior pain and disability relief compared to interlaminar techniques
Specific steroid injections show better results for lower back pain
This meta-analysis of 31 studies involving 2,452 patients evaluated various epidural steroid injection techniques for lumbar radiculopathy. …
A specific type of steroid injection may offer better relief from nerve pain and disability compared to other common injection methods.
Exosomes are safe for knee osteoarthritis but show no superiority over placebo in one trial
Exosomes for knee arthritis: safe but no better than placebo
This systematic scoping review synthesizes evidence on orthobiologics including platelet-rich plasma, cytokine-rich serum, and extracellular…
A review finds exosome injections for knee osteoarthritis are safe, but one trial shows no advantage over placebo.
Serratus anterior plane block reduces postoperative nausea and opioid consumption after surgery under general anesthesia
Serratus Anterior Block May Reduce Nausea After Surgery
This meta-analysis of 1,651 patients found that serratus anterior plane block (SAPB) reduced the incidence of postoperative nausea (RD = -0.…
A new nerve block technique may help reduce nausea and vomiting after surgery while lowering the amount of pain medication patients need.
Spinal cord stimulation research skewed by region and industry funding, meta-analysis finds
Spinal cord stimulation research skews by region and funding
This meta-analysis of 187 studies on spinal cord stimulation for chronic pain found geographic disparities in patient age and research conce…
A global review of 187 studies finds spinal cord stimulation research is unevenly distributed, with funding and patient ages varying by regi…
Hydrolyzed collagen peptides show a cautious signal for improving pain and function in tendon injuries
Collagen Peptides May Help Manage Pain From Tendon and Ligament Tears
This narrative synthesis evaluates the impact of oral or injectable hydrolyzed collagen peptides on patients with tendon and ligament tears.…
New research suggests that collagen peptides may improve pain and function for people recovering from tendon and ligament injuries like Achi…
Pain may precede Parkinson's diagnosis, affecting up to 59% before motor symptoms
Pain may signal Parkinson's before motor symptoms
This narrative review examines pain as an early feature of Parkinson's disease, reporting prevalence up to 59% before motor symptoms and up …
Pain can strike years before Parkinson's motor symptoms, affecting up to 72% of early-stage patients. Recognizing it could speed diagnosis.
Manual acupuncture and sham therapies both reduce pain intensity in tension-type headache patients
Acupuncture Shows Promise for Reducing Tension-Type Headache Pain
This systematic review and network meta-analysis of 6 RCTs involving 1,055 participants found that manual acupuncture, SATV, and SATS all im…
New research suggests that both real and sham acupuncture may help reduce the intensity of tension-type headaches compared to no treatment.
ECAP-controlled closed-loop spinal cord stimulation provides 90% overall pain relief for neuropathic pain
Spinal Cord Stimulation Shows Promise for Chronic Neuropathic Pain
This meta-analysis of 453 adults with chronic pain indicates that ECAP-controlled closed-loop spinal cord stimulation (CL-SCS) achieves a 90…
A new type of spinal cord stimulation shows high rates of pain relief and improved quality of life for adults with chronic nerve pain.
Spinal cord stimulation with medical management reduces pain intensity in painful diabetic neuropathy
Spinal Cord Stimulation Shows Promise for Diabetic Neuropathy Pain
This meta-analysis of adults with painful diabetic neuropathy found that spinal cord stimulation combined with conventional medical manageme…
Adding spinal cord stimulation to standard medical care may significantly reduce pain intensity for adults living with painful diabetic neur…
Comparative Efficacy of Neuromodulation Techniques for Managing Chronic Herpes Zoster Pain
Combination therapies may improve pain for herpes zoster patients
A network meta-analysis evaluates SCS, PNS, and PRF combinations, identifying superior pain reduction and reduced medication reliance.
Combining different nerve stimulation techniques may provide better pain relief and lower medication needs for those suffering from herpes z…
Dexmedetomidine added to TAP block reduces tramadol consumption and pain scores during cesarean section
Dexmedetomidine helps manage pain for women during C-sections
This meta-analysis of 799 women undergoing spinal anesthesia for cesarean section found that dexmedetomidine in a TAP block significantly re…
Adding dexmedetomidine to local anesthesia can delay the need for pain medicine and lower reported pain scores for women undergoing C-sectio…