Natural products modulate non-apoptotic cell death to bypass apoptotic blockades in cancer
Natural products may help cancer cells bypass treatment resistance
This systematic review synthesizes preclinical evidence that natural products can induce ferroptosis, pyroptosis, cuproptosis, and disulfidp…
Certain natural products could trigger specific cell death pathways to overcome hurdles in cancer treatment and improve the body's immune re…
Spatio-temporal graph neural networks improve prediction accuracy and interpretability for regional disease risk modeling
New computer models improve accuracy for predicting regional disease risks
This systematic review of 76 core studies evaluates spatio-temporal graph neural networks (ST-GNNs) and multi-source data fusion. The author…
Advanced graph neural networks are showing more promise than traditional methods for tracking and predicting where diseases might spread nex…
VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
Virtual reality helps manage knee osteoarthritis pain and function
This systematic review and meta-analysis found that virtual reality (VR)-assisted physiotherapy significantly improves pain, physical functi…
Using virtual reality during physical therapy can provide better pain relief and improved balance for people with knee osteoarthritis.
Percutaneous Cervical Cordotomy reduces pain and opioid consumption in patients with severe cancer pain
Procedure Shows Relief for Severe Treatment Resistant Cancer Pain
This meta-analysis of randomized controlled trials evaluates percutaneous cervical cordotomy (PCC) for managing treatment-resistant cancer p…
A surgical procedure called percutaneous cervical cordotomy may reduce severe cancer pain and lower the amount of opioids needed by patients…
Methadone shows significantly higher treatment retention than buprenorphine-naloxone in patients with Opioid Use Disorder
Methadone beats buprenorphine for opioid treatment retention
This meta-analysis of 7 randomized controlled trials involving 3622 patients found that methadone is associated with significantly higher tr…
Methadone keeps more people in opioid treatment than buprenorphine-naloxone, but the combo drug has fewer serious side effects.
Empowered Relief trial evaluates if 1-session intervention is non-inferior to 8-session CBT for chronic pain
Trial Plans to Compare Short and Long Pain Interventions
This randomized comparative effectiveness study protocol aims to evaluate the efficacy of a 1-session Empowered Relief (ER) behavioral inter…
A new trial will compare a single online session of behavioral therapy against an eight-session program for managing chronic pain.
Nitrous oxide reduces pain and improves completion rates in office hysteroscopy
Nitrous oxide reduces pain during office hysteroscopy procedures
This single-center RCT of 214 women found that inhaled nitrous oxide significantly reduced intraprocedural pain and improved procedure compl…
Inhaled nitrous oxide significantly lowers pain and improves patient satisfaction for women undergoing office operative hysteroscopy.
Esketamine reduces 3-month postpartum depression incidence from 20.89% to 11.59% in primiparae
Trial shows esketamine reduces postpartum depression risk in new mothers
This randomized controlled trial of 322 primiparae found that a single dose of esketamine significantly reduced the incidence of postpartum …
A clinical trial suggests that a single dose of esketamine during C-section surgery may lower the risk of developing postpartum depression.
Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
Surgeons performing nerve blocks may help patients leave hospital sooner
This randomized controlled trial of 200 patients undergoing total knee arthroplasty found no significant difference in time to discharge bet…
A new trial shows that surgeons performing specific nerve blocks for knee surgery provide similar pain relief and discharge times as anesthe…
Opioid Wizard tool increases primary care clinician confidence in screening, diagnosing, and referring patients for OUD
Digital Tool Improves Clinician Confidence in Managing Opioid Use Disorder
This secondary analysis of an RCT evaluates the Opioid Wizard clinical decision support tool's impact on primary care clinicians managing op…
A new digital decision support tool helps primary care doctors feel more confident when screening and diagnosing patients with opioid use di…
Intermittent hypoxia-hyperoxia therapy significantly improves pain and functional mobility in musculoskeletal dysfunctions
Intermittent Hypoxia Hyperoxia Therapy May Help Relieve Chronic Muscle and Joint Pain
This meta-analysis of 321 adults with musculoskeletal dysfunctions found that intermittent hypoxia-hyperoxia therapy (IHHT) significantly im…
A review of studies shows that a specific oxygen therapy can significantly reduce pain and improve daily movement for adults with muscle iss…
Tai Chi significantly reduces pain and improves functional disability in chronic non-specific low back pain
Tai Chi helps manage chronic low back pain and disability
This meta-analysis of randomized controlled trials involving 526 patients found that Tai Chi significantly reduced pain (MD -1.40) and impro…
Tai Chi may offer a safe way to reduce chronic low back pain and improve daily physical function for those living with the condition.