Systematic review details McCune-Albright syndrome prevalence, genetics, and clinical framework
Review summarizes current understanding of rare McCune-Albright syndrome
A systematic review synthesizes evidence on McCune-Albright syndrome (MAS), a rare mosaic disorder. It estimates prevalence at 1 in 100,000 …
McCune-Albright syndrome is a rare genetic condition affecting bone, skin, and hormones, caused by random early-life mutations in the GNAS g…
Meta-analysis finds CRP has moderate accuracy for diagnosing diabetic foot osteomyelitis
C-reactive protein test shows moderate accuracy for diabetic foot bone infection
A meta-analysis of 12 studies (n=1828) and retrospective cohort (n=265) evaluated CRP for diagnosing diabetic foot osteomyelitis. Pooled sen…
A common blood test shows moderate accuracy for spotting bone infections in diabetic foot wounds, but results vary across studies and may mi…
Rituximab with prednisone reduced proteinuria in Sjögren's syndrome-associated membranous nephropathy case
Rituximab treatment reduced kidney protein loss in one Sjögren's syndrome patient
A case report describes a 48-year-old female with primary Sjögren's syndrome and nephrotic-range proteinuria treated with prednisone and rit…
A 48-year-old woman with Sjögren's syndrome saw her kidney protein loss drop from 8.5 to 2.2 grams after receiving rituximab treatment.
Tirzepatide improves patient-reported physical function in adults with overweight or obesity
Tirzepatide may improve physical function for adults with overweight or obesity
A meta-analysis of 4,531 participants found that once-weekly tirzepatide 10 or 15 mg significantly improved physical function scores compare…
Adults with overweight or obesity taking tirzepatide reported better physical function scores on two questionnaires compared to those taking…
Network meta-analysis compares exercise types for insulin resistance in youth with overweight or obesity
Which exercise works best for insulin resistance in kids with extra weight?
A network meta-analysis of 63 RCTs involving 3,286 children and adolescents with overweight or obesity compared exercise modalities. HIIT wa…
For kids with extra weight, short bursts of intense exercise best lower insulin levels, while mixing cardio and weights works best for dropp…
Narrative review explores hepatokines and hepato-ovarian axis in PCOS metabolic disorders
Could your liver be talking to your ovaries? A new PCOS theory emerges.
A narrative review summarizes existing evidence on the association between PCOS, glycolipid metabolic disorders, and hepatokines in women of…
A new theory suggests the liver and ovaries constantly signal each other, creating a cycle that links PCOS with fatty liver and blood sugar …
Meta-analysis links elevated atherogenic index of plasma to increased fatty liver disease risk
Blood fat marker linked to higher risk of fatty liver disease in adults
A systematic review and meta-analysis of 20 observational studies in 245,571 adults found elevated atherogenic index of plasma (AIP) was sig…
A simple blood marker called AIP is linked to three times higher odds of having fatty liver disease, offering doctors a new clue for early s…
SGLT2 inhibitors reduce weight and fat mass in older adults with T2DM, with smaller muscle mass decline
SGLT2 diabetes drugs reduce weight and fat in older adults, with small muscle loss
A meta-analysis of 8 RCTs in 541 older adults with Type 2 diabetes found SGLT2 inhibitors significantly reduced body weight (SMD=-0.85) and …
SGLT2 diabetes drugs help older adults lose weight and fat, but they also cause a small, measurable drop in muscle mass that doctors should …
Historical overview traces evolution of hypoparathyroidism treatment toward hormone replacement
Historical review shows how treatment for hypoparathyroidism has evolved over time
A systematic review and historical overview describes the evolution of hypoparathyroidism management. Therapeutic strategies have progressed…
Doctors are moving away from calcium supplements to replace missing hormones naturally with new treatments for hypoparathyroidism.
GADA test shows high specificity but moderate sensitivity for adult-onset type 1 diabetes
How well does a common blood test spot adult-onset type 1 diabetes?
A systematic review and meta-analysis of 11,760 adults with newly diagnosed diabetes found GADA testing had pooled sensitivity of 0.53 and s…
A common blood test misses half of adult-onset type 1 diabetes cases, meaning a negative result doesn't fully rule out the disease.
Offline peer support improves BMI and glucose in type 2 diabetes; hybrid support reduces HbA1c
Offline peer support linked to better weight and blood sugar in type 2 diabetes
A systematic review and meta-analysis of adults with type 2 diabetes found offline peer support significantly improved body-mass index and f…
In-person peer support for type 2 diabetes improved weight and blood sugar, while mixing online and offline help lowered long-term blood sug…
RAI therapy shifts hyperthyroidism to hypothyroidism in HRAS-mutated HGDTC with hyperfunctioning metastases
Radioactive iodine therapy helped one patient with rare thyroid cancer metastases
A case report and literature review describes a 68-year-old woman with HRAS-mutated high-grade differentiated thyroid carcinoma (HGDTC) and …
Radioactive iodine therapy successfully treated a rare case of thyroid cancer that had spread to the lungs and bones while overproducing hor…