Observational study links semaglutide dose and weight loss to lower liver disease risk
Study links semaglutide use to lower risk of several liver conditions in patients with liver disease
This observational study from a real-world federated EHR network analyzed 6,734 patients with liver disease.
Higher semaglutide doses and greater weight loss were linked to lower risks of steatohepatitis, alcoholic liver disease, and death in patien…
Monitoring report on US GLP-1 RA prescribing trends shows increased oral semaglutide use
Why are so many people getting new diabetes and weight-loss drugs?
This monitoring report analyzes real-world US electronic health record data from Truveta on GLP-1 RA prescribing.
Prescriptions for diabetes and weight-loss drugs jumped sharply in the US after a new oral pill was approved, with first-time use rising ove…
NHANES observational review links current smoking to higher HbA1c in non-diabetic adults
Smoking Raises Blood Sugar in People Without Diabetes
This observational analysis of NHANES 2015-2018 data found that current smoking was significantly associated with higher HbA1c among adults …
Quitting smoking may help protect your blood sugar levels, even if you don't have diabetes yet.
Review of UK Biobank data identifies plasma protein mediators in cardiometabolic disease progression
New Blood Test Clues Could Predict Diabetes Complications Years Earlier
This observational review analyzes UK Biobank data from 53,030 participants to evaluate plasma proteins as mediators in secondary disease de…
A new blood test spots specific proteins that warn of heart, kidney, and brain problems years before they happen in people with diabetes or …
Preclinical spatial transcriptomics study maps IMAT gene signature in cardiometabolic disease mouse model
Fat inside your muscles may be rewiring your health—here’s how
This primary preclinical research uses spatial transcriptomics to map human intermuscular adipose tissue (IMAT) gene signatures in a mouse m…
Hidden fat inside your muscles may be rewiring your health by changing how they work, offering new hope for treating metabolic disease.
Narrative review explores CSF1R inhibitor potential in pediatric medulloblastoma precision immunotherapy
The Hidden Reason Children's Brain Tumors Respond So Differently to Treatment
This narrative review examines the role of CSF1R inhibitors as precision immunotherapy for pediatric medulloblastoma subtypes.
Each subtype of children's brain tumors has a unique immune fingerprint, meaning matching treatment to that specific environment could drama…
Weight stigmatization increases physiological stress and appetite markers in women with obesity over 120 minutes
Being Judged for Your Weight Can Change Your Body Chemistry Fast
This randomised feasibility study examined 18 women living with obesity exposed to a weight-stigmatising paradigm versus a non-stigmatising …
Even a brief moment of weight-based judgment may set off a chain of physical stress responses — including hormonal changes that drive hunger…
Cochrane review finds very low-certainty evidence on IGF-1 for ROP in preterm infants
Premature Babies and Eye Disease: A Hopeful Treatment Hits a Wall
This Cochrane systematic review synthesized evidence from two RCTs on IGF-1 for retinopathy of prematurity in preterm infants.
A promising hormone-based treatment for a leading cause of infant blindness has been tested in clinical trials, but the evidence is too thin…
Narrative review discusses lipid levels in normal range regarding metabolic and endocrine disease risk
Your Cholesterol Is "Normal" — But Is It Really Safe?
This narrative review explores the relationship between blood lipid levels within the normal reference range and the risk of major metabolic…
Even within normal ranges, small shifts in blood fat levels may quietly raise your odds of diabetes, thyroid issues, and other hormonal dise…
Meta-analysis links diabetic retinopathy with anxiety and depression in over 383,000 patients
Diabetes Eye Disease and Depression Feed Each Other — and Doctors Are Just Catching On
This meta-analysis synthesizes observational data from 383,195 patients with diabetic retinopathy and/or diabetes mellitus to evaluate the a…
Diabetic eye disease and depression trap patients in a two-way cycle where each condition significantly raises the risk of the other.
Three-parameter online nomogram predicts diabetic retinopathy risk in community-dwelling type 2 diabetes patients
Three Numbers Could Tell Your Doctor If Your Eyes Are at Risk
This retrospective cohort study evaluated a three-parameter online nomogram using diabetes duration, HbA1c, and high BMI (≥24 kg/m²) to pred…
A free, web-based calculator using only your diabetes duration, blood sugar control, and BMI could help doctors spot who needs an urgent eye…
Inflammatory and metabolic indices associated with microvascular complications in hospitalized type 2 diabetes patients
Two Blood Markers Could Predict Serious Diabetes Complications Years Earlier
This retrospective cohort study examined 964 hospitalized patients with type 2 diabetes to assess associations between inflammatory and meta…
Two blood scores measuring inflammation and metabolic stress may predict serious diabetes complications years before symptoms appear.