Same-day ART initiation non-inferior to waiting for TB results for viral suppression in people with HIV
Study finds same-day HIV treatment works as well as waiting for tuberculosis test results
A randomized non-inferiority trial in 590 people with HIV and TB symptoms in Lesotho and Malawi found same-day ART initiation was non-inferi…
People with HIV and tuberculosis symptoms get their virus controlled just as well when starting treatment the same day as waiting for test r…
Phase 1 trial shows linear pharmacokinetics and good tolerability for HRS-8427 in healthy Chinese adults
Can a new antibiotic candidate be safely tested in people? Early results look promising.
A phase 1 randomized controlled trial in 79 healthy Chinese adults evaluated the pharmacokinetics and safety of intravenous HRS-8427. Single…
A new antibiotic candidate shows promising early safety results in healthy adults, with predictable dosing and no serious side effects repor…
Intrapartum azithromycin reduces maternal infection risk regardless of time to delivery
Study finds timing of antibiotic in labor may not affect maternal infection prevention
A secondary analysis of an RCT in 29,236 pregnant patients found intrapartum azithromycin reduced maternal infection risk (RR 0.71) regardle…
Giving azithromycin during labor cuts maternal infection risk by 29% regardless of timing, but offers no protection for newborns.
Favipiravir PEP shows non-significant reduction in SARS-CoV-2 infection among household contacts in Thailand trial
Can a pill protect you after a family member gets COVID?
A phase 2/3 cluster-randomized trial in 168 Thai household contacts of COVID-19 cases compared favipiravir PEP (1600-2000 mg/day for 7 days)…
Taking an antiviral pill after a family member gets COVID might lower infection rates and delay symptoms, though the study's main findings w…
Tigecycline monotherapy shows no outcome disadvantage versus combination therapy for MDR gram-negative infections in retrospective cohort
Study finds no clear benefit of combination therapy over tigecycline alone for resistant infections
A retrospective cohort study of 280 hospitalized adults with MDR gram-negative infections found no independent association between tigecycli…
Combining antibiotics with tigecycline offers no clear benefit over using the drug alone for treating severe, drug-resistant bacterial infec…
Symptom clusters from participatory surveillance data align with specific respiratory pathogens in Dutch and Italian cohorts
Can your cough tell you which virus you have? Symptom patterns may hold clues.
An observational cohort study of symptomatic participants in Dutch and Italian participatory surveillance platforms used Non-negative Matrix…
Certain cough and cold symptom patterns consistently point to specific viruses like SARS-CoV-2 or the flu across different European countrie…
CCHFV detected in Hyalomma ticks in western Spain with 1.54% infection rate
Study finds Crimean-Congo fever virus in ticks from western Spain
A retrospective surveillance study of 3,183 ticks from western Spain found Crimean-Congo hemorrhagic fever virus exclusively in Hyalomma lus…
Ticks in western Spain carry Crimean-Congo fever virus, found mostly in red deer and one specific tick type, prompting health officials to k…
Hospital-wide antimicrobial TDM program shows 50% therapeutic attainment and significant inter-departmental heterogeneity
Hospital-wide antibiotic monitoring program shows uneven use and mixed results
A retrospective cohort study of 1,928 inpatients at a Chinese tertiary hospital found that after implementing a hospital-wide antimicrobial …
A new hospital antibiotic monitoring program shows uneven use across departments and mixed results, with only half of drug levels hitting th…
Case report finds West Nile virus encephalitis in immunocompromised child after transfusions
Case report links West Nile virus infection to blood transfusions in Saudi Arabia
A case report with cross-sectional donor screening describes a 4-year-old Saudi girl with Ewing's sarcoma who developed WNV encephalitis aft…
A 4-year-old Saudi girl with cancer developed a serious brain infection after receiving blood transfusions, highlighting risks for vulnerabl…
Genomic analysis of ceftazidime/avibactam-resistant Klebsiella pneumoniae isolates from transplant unit
Italian study finds resistant bacteria in transplant unit carry multiple concerning genes
A retrospective cohort study of 14 clinical isolates from an Italian transplant unit found most ceftazidime/avibactam-resistant Klebsiella p…
Resistant bacteria in an Italian transplant unit carry multiple drug-resistance genes and traits that help them cause disease.
Retrospective study finds 61% of vaccinated, boostered individuals neutralize Wuhan-Hu-1 SARS-CoV-2 variant
How well do vaccine antibodies fight different COVID variants?
A retrospective cohort study of 100 vaccinated and boostered individuals found 61% effectively neutralized the Wuhan-Hu-1 SARS-CoV-2 variant…
Most vaccinated people's antibodies stopped the original virus, but only a few could also block newer variants like Beta, Delta, and Omicron…
Phase 1 study finds molnupiravir 800 mg well-tolerated with no NHC accumulation in healthy Chinese adults
How does a COVID-19 pill behave in the body? A small study in healthy men offers clues.
An open-label, fixed-sequence Phase 1 study in 16 healthy male Chinese adults evaluated the pharmacokinetics and safety of oral molnupiravir…
Understanding how a drug moves through the body is a crucial first step. A small, early study in healthy Chinese men found the active part o…