Upadacitinib shows 94.1% remission at 26 weeks in Crohn's disease cohort
Study compares upadacitinib and other therapies for Crohn's disease remission
This retrospective cohort study of 218 individuals with Crohn's disease found a 94.1% clinical remission rate at 26 weeks for upadacitinib, …
Upadacitinib showed a 94.1% remission rate for Crohn's disease patients at 26 weeks, but this finding comes from a very small group of just …
Obesity associated with reduced SLE relapse rates in Japanese registry cohort
A Surprising Link Between Weight and Lupus Flares
This observational cohort study of 1134 patients with systemic lupus erythematosus in Japan found that obesity (BMI ≥25 kg/m2) was associate…
Being overweight or mildly obese might lower the risk of lupus relapses, challenging common beliefs about weight and autoimmune disease.
Meta-analysis links chronic kidney disease to higher mortality after intracerebral hemorrhage
Kidney Disease Linked to Higher Stroke Death Risk
This meta-analysis of 5,000 patients with spontaneous intracerebral hemorrhage found that chronic kidney disease was associated with higher …
Kidney disease makes surviving a brain bleed much harder, raising the risk of death and disability for patients with this common condition.
Masitinib 4.5 mg/kg/day associated with survival in ALS post-hoc analysis
This Drug Could Add Nearly Two Years to ALS Life
This post-hoc analysis of a randomized, double-blind, placebo-controlled trial in 130 ALS patients found that masitinib 4.5 mg/kg/day was as…
A new look at data suggests a specific drug might significantly extend life for some people with ALS.
Intermittent theta-burst stimulation of right putamen improves motor scores in Parkinson's disease patients.
New Non-Invasive Method Eases Parkinsons Motor Symptoms Without Surgery
This randomized controlled trial in 19 Parkinson's disease patients found that intermittent theta-burst transcranial temporal interference s…
A new non-surgical brain treatment showed promise in reducing movement problems for Parkinsons patients.
Meta-analysis links speech features to severity in Parkinsons, cerebral palsy, and ALS
Speech patterns may help track disease severity in Parkinsons and other conditions
This meta-analysis synthesizes evidence from 890 speakers across 5 languages to evaluate a training-free method for assessing speech degrada…
A new computer method tracks Parkinson's and other disease severity by measuring how specific speech sounds change without needing special t…
Telemedicine network associated with lower 90-day mortality and care needs in rural acute neurological disorders.
Could a 24/7 telemedicine network help rural hospitals save lives after a stroke or brain injury?
This prospective cohort study in rural northeast Germany evaluated a digitally enabled hub-and-spoke telemedicine network for adults with ac…
Rural hospitals using a 24/7 telemedicine network saw lower death or nursing home rates for stroke patients compared to similar facilities w…
Neutrophil SIRL-1/IL-8 Ratio as a Diagnostic Biomarker for Inflammatory Bowel Disease
New Blood Ratio Could Spot IBD Faster
This single-center cohort study measured neutrophil SIRL-1 and serum IL-8 in 90 IBD patients and healthy volunteers. The SIRL-1/IL-8 ratio s…
A new blood ratio measuring two immune signals could help doctors diagnose Crohn's and Ulcerative Colitis faster and more accurately.
SHAP-based model predicts pneumonia after aneurysmal subarachnoid hemorrhage embolization
Doctors Can Now Predict a Dangerous Complication After Brain Bleeds
This retrospective cohort study of 290 patients with aneurysmal subarachnoid hemorrhage evaluated a prediction model for stroke-associated p…
Doctors can now predict who will develop pneumonia after a brain bleed, allowing faster action to save lives.
Observational cohort finds high cardiac involvement and variable treatment patterns in hATTR patients.
Heart Treatment Often Misses Nerve Damage in This Group
This single-center retrospective cohort study of 54 patients with hereditary transthyretin amyloidosis (hATTR) found 94.4% had cardiac invol…
Heart patients with a common African American gene variant often get nerve damage missed, leaving tingling hands untreated while doctors foc…
Plasma proteomics profiling reveals differential protein expression in Alzheimer's and frontotemporal dementia
Can a simple blood test tell Alzheimer's from frontotemporal dementia?
An observational cohort study of 101 Asian individuals with known pTau217 status used plasma proteomics profiling to identify 1,168 proteins…
A simple blood test could distinguish Alzheimer's from frontotemporal dementia by spotting unique protein patterns linked to brain inflammat…
Etalanetug reduces CSF tau biomarkers in dominantly inherited Alzheimer's disease in phase 1b/2 study.
Can a new drug slow Alzheimer's toxic tau protein in the brain?
This open-label phase 1b/2 study in 8 participants with mild-to-moderate cognitive impairment due to dominantly inherited Alzheimer's diseas…
An early study shows an experimental drug lowers two key tau proteins in spinal fluid for people with a rare inherited form of Alzheimer's.