6-metabolite blood biomarkers aid differential diagnosis of Parkinson's disease versus healthy controls and other neurodegenerative conditions.
Can a simple blood test tell the difference between Parkinson's and other brain diseases?
This observational study assessed a 6-metabolite blood biomarker (6M-BB) profiled by 1H NMR for distinguishing Parkinson's disease (PD) from…
A simple blood test using six metabolites correctly identified Parkinson's disease in nearly 95% of cases while distinguishing it from other…
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants.
Can computer programs match human experts at reading your sleep data?
This study evaluated machine-learning models for sleep stage classification, arousal detection, and respiratory event detection using overni…
Smart computer models can match human experts at reading sleep data for stages and wake-ups, though they still lag behind humans when spotti…
Global bibliometric analysis reveals neuroendoscopy research evolution from conservative treatment to augmented reality over two decades.
How has global research on brain surgery for bleeding changed over the last twenty years?
This bibliometric review analyzed 403 articles from authors at 555 institutions across 43 countries regarding neuroendoscopy for intracrania…
Global brain surgery research has shifted from proving safety to refining precise, high-tech treatments for bleeding over the last twenty ye…
In Parkinson's disease, OFF predictability and clinical features explain more OFF impact variance than OFF time.
Study finds predictability of Parkinson's OFF episodes matters more than their duration
This observational review analyzed 1,252 OFF-only visits from 430 PPMI participants to identify correlates of OFF burden. Clinical features …
Parkinson's OFF episodes hurt more when they are unpredictable, not just when they are long, as new data shows predictability matters most f…
Hierarchical Barycentric Framework Shows Consistent Improvements in Brain Tumor MRI Analysis
New AI method shows consistent improvements in brain tumor MRI analysis tasks.
A preprint computational study proposes a novel Hierarchical Barycentric Multimodal Representation Learning framework for medical imaging. T…
A new AI method consistently improves how medical images analyze brain tumors, offering a more robust way to handle missing data in scans.
Customized 3D-printed PMMA molds yielded satisfactory aesthetics in 87.5% of eight cranioplasty patients.
Small study finds 3D-printed molds help create custom cranioplasty implants with good results
This retrospective case series evaluated customized polymethylmethacrylate (PMMA) implants fabricated using 3D-printed molds in eight patien…
3D-printed molds helped create custom skull implants with good results in a small group of patients, offering a low-cost option for cranial …
Connectomics-guided meta-learning framework decoded sleep spindles in 17 Parkinson's disease patients with DBS implants.
New method predicts sleep spindles in Parkinson's patients with high accuracy
This clinical study evaluated a connectomics-guided meta-learning framework in 17 patients with Parkinson's disease and bilateral deep brain…
A new system predicts sleep spindles in Parkinson's patients with 83% accuracy two seconds ahead, offering a path to target sleep disturbanc…
FDA Approves Gabapentin Capsules (gabapentin) for Postherpetic Neuralgia and Partial Onset Seizures
FDA approves a new generic version of the drug gabapentin for nerve pain and seizures.
The FDA has approved Gabapentin Capsules, USP for the management of postherpetic neuralgia in adults and as adjunctive therapy for partial o…
FDA approves a new generic gabapentin capsule for nerve pain and seizures, offering patients another low-cost treatment option alongside exi…
Meta-analysis finds no significant differences between pCASL and DSC perfusion MRI in hyperacute ischemic stroke
MRI technique shows promise for stroke imaging but evidence remains limited
A systematic review and meta-analysis of 383 ischemic stroke patients found no significant differences between pseudocontinuous arterial spi…
A new MRI scan that avoids injected dye shows similar results to standard tests for detecting early stroke damage, though more research is n…
Systematic review examines neuroprotective plant extracts for Parkinson's disease mechanisms
Review explores how plant extracts might protect brain cells in Parkinson's disease
A systematic review summarized preclinical and clinical research on plant extracts with neuroprotective properties for Parkinson's disease. …
Plant extracts might protect brain cells in Parkinson's disease by reducing inflammation, stopping protein clumping, and helping nerve conne…
NeuroFM foundation model enables brain health profiling and dementia risk estimation from MRI
Can a single brain scan model predict your future dementia risk?
A cohort study evaluated NeuroFM, a foundation model trained on 100,000 synthetic brain volumes and tested on 136,361 real volumes. The mode…
A new brain scan model learned from healthy images to spot dementia risk years before diagnosis without needing disease labels.
FDA Approves Valproic Acid Oral Solution (valproic acid) for Monotherapy and Adjunctive Therapy of Complex Partial and Absence Seizures
FDA approves a liquid form of an existing epilepsy medicine called valproic acid.
The FDA has approved valproic acid oral solution for monotherapy and adjunctive therapy of complex partial seizures, and as sole and adjunct…
FDA approves liquid valproic acid for epilepsy patients 10 and older who struggle to swallow pills or need flexible dosing.