Ifinatamab deruxtecan shows antitumor activity in advanced treatment-refractory solid tumors in phase 1/2 trial
Early trial shows experimental drug shrinks tumors in some patients with advanced cancers
This first-in-human phase 1/2 trial of 97 patients with advanced treatment-refractory solid tumors found a confirmed objective response rate…
An early trial of a new experimental drug shrank tumors in 34% of patients with advanced cancers that had stopped responding to standard tre…
Lu-PSMA-617 plus pembrolizumab shows PSA response in mCRPC phase 1b/2 trial
Can a new drug combo help men with advanced prostate cancer?
In a single-arm phase 1b/2 trial of 37 patients with mCRPC, Lu-PSMA-617 plus pembrolizumab achieved a 50% PSA decline in 28 participants (76…
A new drug combo helped 28 of 37 men with advanced prostate cancer cut their PSA levels in half while keeping side effects mostly mild to mo…
Fulzerasib plus cetuximab shows 69% response in first-line KRAS-mutated NSCLC
Can a new drug combination shrink lung tumors in people with a specific KRAS mutation?
A single-arm phase 1b/2 trial in 47 treatment-naive patients with KRAS-mutated NSCLC found a confirmed objective response rate of 69% (90% C…
A new two-drug combination shrank tumors in nearly 70% of people with advanced lung cancer driven by a specific genetic mutation.
Case report: Low-intensity chemotherapy achieves remission in PMF transformed to MPAL
Single case report describes treatment for rare leukemia transformation in elderly patient
A case report describes a 75-year-old female with JAK2V617F-positive primary myelofibrosis that transformed to mixed phenotype acute leukemi…
A 75-year-old woman with rare leukemia transformation from blood disorder achieved remission after two cycles of low-intensity chemotherapy.
Radiomics models predict progression in lung oligometastases after SABR in phase II trial
Radiomics models show promise for predicting outcomes after lung metastasis radiation
A single-arm phase II trial of 126 patients with lung oligometastases developed radiomics models to predict progression-free survival and ea…
Computer analysis of medical scans can better predict when lung cancer will spread after radiation treatment than standard clinical informat…
Real-world study shows lenalidomide-dexamethasone yields 22.9-month PFS in transplant-ineligible myeloma
Real-world study shows lenalidomide treatment outcomes for older multiple myeloma patients
A prospective, non-interventional study of 168 transplant-ineligible NDMM patients in Germany found median PFS of 22.9 months and OS of 58.1…
Real-world data shows lenalidomide plus low-dose dexamethasone keeps older multiple myeloma patients disease-free for nearly two years while…
Green tea mouth rinse improved oral health scores but not pain or QOL in advanced head and neck cancer patients
Green tea mouth rinse improved oral health in advanced head and neck cancer patients
A 64-patient RCT in palliative care found that adding a green tea-based mouth rinse to usual care significantly improved oral health assessm…
A green tea mouth rinse improved oral health scores for advanced head and neck cancer patients over six weeks, though it did not reduce pain…
Review explores JAK inhibitor combination with PD-1 blockade for overcoming immunotherapy resistance
Review explores combining JAK inhibitors with immunotherapy for resistant cancers
A systematic review discusses the rationale for combining JAK inhibitors with PD-1 blockade immunotherapy based on emerging preclinical and …
Blocking inflammation around tumors with JAK inhibitors may help immune drugs work better for cancers that have stopped responding to standa…
Yoga and relaxation interventions show non-significant effects on psychological outcomes in pediatric cancer caregivers
Can yoga help parents caring for a child with cancer? The evidence isn't clear yet
A systematic review and meta-analysis of six small studies (15-60 participants each) found yoga and relaxation interventions showed favorabl…
Yoga and relaxation may ease stress for parents of children with cancer, but new research shows the evidence isn't strong enough to prove th…
Narrative review explores interkingdom interactions in subgingival microbiome and periodontitis
What if gum disease isn't just about bacteria?
A narrative review synthesizes evidence on host-pathogen interactions involving bacteria, fungi, viruses, and archaea in periodontitis.
Gum disease isn't just about bacteria; fungi and viruses team up with them to make infections worse and damage tissue.
Meta-analysis finds geographical disparities in FIT-based colorectal cancer screening participation
Where you live may affect your chance of getting screened for colon cancer
A systematic review and meta-analysis of 35 studies in average-risk adults aged 40-74 examined geographical disparities in FIT-based CRC scr…
Where you live changes your chances of taking a colon cancer stool test, but the test works equally well everywhere regardless of location.
Review proposes DC-NK metabolic checkpoint concept in viral asthma exacerbations
Why do colds hit people with asthma so hard? A new idea points to exhausted immune cells
A systematic review synthesizes murine and in vitro evidence proposing that dendritic cell-natural killer cell metabolic dysregulation contr…
Asthma colds trigger dangerous flares because stressed immune cells create an acidic environment that exhausts the virus-fighting cells need…