Proton therapy shows dosimetric advantages over photon therapy for prostate cancer treatment
Can proton therapy spare healthy tissue better for prostate cancer patients?
This review summarizes evidence on proton therapy for prostate cancer across treatment settings. Dosimetric outcomes favor proton therapy, p…
Proton therapy spares healthy tissue better than standard radiation for prostate cancer, offering excellent disease control with low rates o…
Comparative genomic profiling of Sezary syndrome and primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Do two rare skin lymphomas hide different mutation clues for treatment?
This observational cohort study analyzed genomic data from 26 patients with Sezary syndrome and 13 with primary cutaneous CD8+ aggressive ep…
Two rare skin lymphomas share nearly identical mutation counts but differ in ERBB2 gene changes, offering new clues for personalized treatme…
Narrative review proposes theoretical applicability of plant non-cancer resistance mechanisms to animal cancer resistance
Plants Never Get Cancer — Could Their Secret Work in Humans Too?
This narrative review synthesizes current literature to propose that fundamental principles of non-cancer resistance (NHR) in plants might a…
Plants never get cancer because of a unique immune logic that scientists now propose could inspire a new way to build cancer-resistant human…
Meta-analysis shows perioperative denosumab increases local recurrence in giant cell tumor patients.
A Common Bone Tumor Drug May Raise the Risk of Cancer Coming Back
This meta-analysis evaluated perioperative denosumab in 1,551 patients undergoing surgical management of giant cell tumor. The authors synth…
Taking a common bone tumor drug before and after surgery nearly tripled the chance of the tumor growing back in a new analysis of 1,551 pati…
Narrative review offers novel perspectives on cancer development via RMP ubiquitination targeting.
Cancer Hijacks a Cellular Recycling System — Scientists Are Learning to Fight Back
This narrative review explores the role of targeting RMP ubiquitination in cancer development. The authors synthesize current knowledge to p…
Cancer cells hijack a hidden recycling loop inside healthy cells to grow and spread, but scientists are now mapping this trick to build new …
Narrative review examines synthetic circRNA therapeutics versus mRNA and saRNA in oncology and rare diseases.
A Ring-Shaped Medicine Could Last Longer Than Anything Before It
This narrative review evaluates preclinical and early translational evidence regarding synthetic (exogenous) circRNA therapeutics compared t…
A ring-shaped RNA molecule could last longer inside the body than standard medicines, potentially helping treat cancer and rare diseases.
SCOPE platform predicts outcomes for metastatic colorectal and pancreatic cancers using organoid screening.
A Lab-Built Tumor Test May Predict If Cancer Drugs Will Work
This preclinical platform development study utilized a machine learning system integrating patient-derived organoids and clinical data to pr…
A platform called SCOPE uses tiny lab-grown copies of a patient's tumor to predict — before a large trial even starts — whether a cancer dru…
Decitabine versus hydroxyurea in advanced chronic myelomonocytic leukemia shows survival differences linked to baseline counts.
Keeping Blood Cell Counts Low in Leukemia Predicts Who Lives Longer
This randomized controlled trial (RCT) enrolled 120 patients with advanced proliferative chronic myelomonocytic leukemia (CMML) comparing de…
In chronic myelomonacytic leukemia, keeping abnormal blood cells low after treatment predicts who lives longer than bone marrow changes alon…
Case report and literature review on T-SMARCA4-DUT diagnosis and treatment response in a single patient
A Rare Tumor That Fooled Doctors at Every Step — Until One Test Changed Everything
This case report and literature review describes a 64-year-old male with thoracic SMARCA4-deficient undifferentiated tumor initially misdiag…
A rare chest tumor mimicking lung cancer was misdiagnosed until a specific genetic test revealed the true cause, proving one marker can prev…
Narrative review explores adipose tissue macrophage regulation for obesity and metabolic disorders
The Immune Cells Inside Fat Tissue That Drive Obesity's Hidden Damage
This narrative review examines targeted regulation of adipose tissue macrophages (ATMs) via mitochondrial, extracellular vesicle, probiotic,…
Specialized immune cells hiding inside your fat tissue are quietly driving the chronic inflammation that damages your heart, liver, and panc…
Review compares 68Ga-pentixafor and 18F-FDG PET/CT in a single CLL patient
A New Scan Spots a Tricky Blood Cancer Far More Clearly
This case report and review of literature evaluates diagnostic performance of 68Ga-pentixafor versus 18F-FDG PET/CT in a 60-year-old woman w…
A new PET scan tracer spots chronic lymphocytic leukemia more clearly than standard imaging, helping doctors see disease extent in patients …
Narrative review assesses AI/ML adherence prediction in chronic disease patients globally with noted limitations.
AI Can Now Predict Who Will Stop Taking Their Medication — Before They Do
This narrative review evaluates artificial intelligence and machine learning approaches for prospective adherence risk prediction in chronic…
AI tools can now predict which patients with chronic diseases like diabetes or HIV will stop taking their medication before it happens, allo…