HS-20093 shows response in lung cancers in Phase 1a/b trial
New Drug Targets Deadly Lung Cancer Cells
A Phase 1a/b trial in 306 patients with previously treated advanced solid tumors found HS-20093, a B7-H3-targeted antibody-drug conjugate, h…
A new drug attacks a specific protein on lung cancer cells, helping more than half of patients with an aggressive type while remaining safe …
Multi-cancer early detection blood test shows variable sensitivity across cancer stages in case-control study
Blood Test Finds Half of Cancers Before Symptoms Start
This case-control study evaluated a multi-target blood test for early cancer detection across 21 tumor types in 6,352 samples. Overall sensi…
A new blood test detects half of all cancers before symptoms appear, catching aggressive types often missed by current screening tools.
Early pilot feasibility report on deep longitudinal profiling in metastatic cancer patients
Early pilot study tests data collection methods for cancer patients
This prospective, multicenter observational study protocol and feasibility report describes an early internal pilot involving 30 female pati…
Researchers enrolled 30 women with newly diagnosed metastatic breast, lung, or colorectal cancer to test how well they could gather long-ter…
Review of pediatric B-ALL CAR-T therapy identifies RAS mutation outcome predictor
New Test Predicts CAR-T Success in Kids
This narrative review synthesizes observational data from 86 pediatric patients with relapsed or refractory B-cell acute lymphoblastic leuke…
A new test can spot hidden genetic risks before a child starts powerful CAR-T cancer therapy.
NIH News in Health issue lists items on DLD, pancreatic cancer test, air pollution, dementia medications
New research looks at pancreatic cancer and dementia, but the details are missing.
This source is an NIH News in Health table of contents listing five consumer-facing items: detecting developmental language disorder (DLD), …
A new test may find early pancreatic cancer, but the study lacks details on who was tested or what results were found.
Review of Virtual Spectral Decomposition for pancreatic cancer detection on CT scans
Virtual spectral decomposition shows promise for detecting pancreatic cancer field effects on standard CT scans.
This review and synthesis evaluates a computational imaging method, Virtual Spectral Decomposition (VSD), applied to standard portal-venous …
A new image analysis method can spot subtle changes in the pancreas on standard CT scans, helping to find early signs of cancer before a tum…
Review finds fine-tuned AI model matches larger model in simulated lung cancer screening conversations
Small AI Model Beats Big Tech in Lung Cancer Chat
This evaluation review assesses a fine-tuned open-source AI model for lung cancer screening conversations, comparing it to a larger propriet…
A specialized, smaller AI model understands patient worries better than a huge, expensive system while keeping patients safe.
Microsimulation review models overdiagnosis and false positives for multicancer screening in Canada
Screening for Cancer May Find Too Much
This review uses a microsimulation model to estimate yearly and cumulative lifetime probabilities of overdiagnosis and false positives for p…
New cancer blood tests might find slow-growing tumors that would never cause sickness, leading to unnecessary treatment and side effects for…
Review of observational data on vaccine antibody levels in children with acute lymphoblastic leukemia
Do routine vaccines work normally for children fighting acute lymphoblastic leukemia?
This narrative review synthesizes observational data regarding routine childhood measles and varicella zoster virus vaccines in children wit…
Children with leukemia have lower antibody levels after measles and chickenpox vaccines, but their immune cells still function well, suggest…
FDA Approves Vanflyta (quizartinib) for Newly Diagnosed FLT3-ITD-Positive AML in Adults
FDA approves new drug called Vanflyta for a specific type of blood cancer in adults.
Vanflyta is approved in combination with induction and consolidation chemotherapy, and as maintenance monotherapy, for adult patients with n…
FDA approves Vanflyta to treat acute myeloid leukemia in adults with a specific genetic change that makes the cancer harder to manage.
Talazoparib plus enzalutamide shows high probability of benefit in Japanese mCRPC subgroup
New Math Brings Hope to Japanese Men With Advanced Prostate Cancer
A Bayesian reanalysis of phase III trial data in 116 Japanese patients with metastatic castration-resistant prostate cancer found a 98% prob…
New math suggests a two-drug combo likely works for Japanese men with advanced prostate cancer, even when original trial numbers looked unce…
Deutenzalutamide improves rPFS in mCRPC after abiraterone and docetaxel progression.
New Pill Slows Advanced Prostate Cancer After Other Drugs Fail
A randomized phase III trial in 417 patients with metastatic castration-resistant prostate cancer after progression on or intolerance to abi…
A new daily pill slowed advanced prostate cancer progression by 42 percent in men whose disease grew despite standard hormone therapy and ch…