Quantitative MRI and clinical data model predicts prostate cancer in patients with lesions
A Smarter MRI Read May Spot Prostate Cancer Without a Biopsy
A retrospective cohort study of 290 patients with prostate lesions found that a prediction model integrating multimodal quantitative MRI and…
A new MRI scoring tool accurately spots prostate cancer in men facing biopsy decisions, potentially sparing them from painful, unnecessary n…
Aerobic exercise remodels tumor vasculature to improve drug delivery and enhance treatment response in cancer.
Why a Few Brisk Walks a Week Could Make Cancer Drugs Work Better
This review synthesizes evidence indicating that aerobic exercise remodels tumor vascular function and the microenvironment to improve drug …
Growing research suggests that regular aerobic exercise can reshape the chaotic blood vessels feeding a tumor, helping cancer drugs penetrat…
Adherence to 2021 ABS imaging recommendations in 148 male breast referrals at a UK hospital
Why Most Lumps in Men Don't Need a Mammogram, but Many Still Get One
This retrospective observational cohort study evaluated adherence to 2021 ABS imaging recommendations among 148 male patients referred to a …
A year-long UK clinic review found that most men referred for breast lumps had benign conditions, yet imaging was often done despite nationa…
CD19/BCMA CAR-T cells show early signal in six patients with refractory generalized myasthenia gravis
A One-Time Treatment Lets Patients with Severe Muscle Disease Stop Their Steroids
A Phase 1 study of 6 patients with refractory generalized myasthenia gravis found autologous CD19/BCMA CAR-T cells without prior lymphodeple…
A one-time infusion of engineered immune cells allowed patients with a debilitating muscle-weakening disease to stop steroids and live sympt…
AN+AD combination therapy yields high response rates in nonbulky classical Hodgkin lymphoma patients.
A New Treatment Path for Hodgkin Lymphoma Shows Stunning Success
This Phase 2 study evaluated AN+AD (brentuximab vedotin, nivolumab, doxorubicin, and dacarbazine) in 154 patients with nonbulky classical Ho…
A promising new treatment approach for early-stage Hodgkin lymphoma is delivering remarkable results with less intensive chemotherapy.
BCMA CAR-T therapy achieves 100% MRD negativity in transplant-ineligible multiple myeloma patients.
A One-Time Treatment Erases Early-Stage Blood Cancer in Older Adults
This Phase II, open-label, single-arm trial evaluated BCMA CAR-T infusion in 36 patients with newly diagnosed multiple myeloma ineligible fo…
A new approach using a patient’s own re-engineered immune cells is showing unprecedented success in wiping out a common blood cancer from th…
Exploratory RCT finds in situ vaccine plus PD-1 with immunoradiotherapy shows response in advanced hepatic malignancies
New Vaccine Combo Shrinks Liver Tumors Safely
An exploratory RCT of 18 patients with advanced hepatic malignancies compared in situ vaccine FOLactis plus PD-1 antibody combined with eith…
A new vaccine combo shrinks liver tumors safely without the severe side effects usually caused by strong cancer drugs.
Trifluridine/tipiracil plus irinotecan and bevacizumab in metastatic colorectal cancer resistant to prior chemotherapy
A New Second-Line Combo Shows Promise for Advanced Colon Cancer
This multicenter, single-arm, phase II trial evaluated biweekly trifluridine/tipiracil, irinotecan, and bevacizumab in 60 patients with meta…
For patients whose advanced colon cancer has stopped responding to initial chemo, a new drug combination is showing it can effectively fight…
Radical perineal prostatectomy shows lower blood loss but similar long-term outcomes to retropubic approach
A New Cut Saves Blood, Keeps Cancer Control
A 10-year follow-up RCT in 103 men with localized prostate cancer found radical perineal prostatectomy (RPP) had significantly lower estimat…
A smaller cut between the scrotum and anus matches the standard belly incision for keeping cancer away while reducing blood loss during pros…
Sequential paclitaxel-palbociclib showed no difference in ORR versus reverse sequence in ER+/HER2- breast cancer.
New Test Predicts Who Needs Chemo in Breast Cancer
This randomized phase II trial evaluated sequential administration of paclitaxel and palbociclib with endocrine therapy in patients with ER+…
Doctors now have a way to spot patients who can skip chemo and go straight to safer hormone treatment.
Splenectomy versus spleen preservation during total gastrectomy for gastric cancer in adults
Should your surgeon remove your spleen during stomach cancer surgery?
This systematic review of randomized controlled trials evaluated adults undergoing total gastrectomy for gastric cancer in Asia and South Am…
Removing the spleen during stomach cancer surgery may be unnecessary and increases infection risks, challenging a long-standing practice.
PARP inhibitors significantly improve progression-free survival in BRCA-mutated ovarian cancer patients.
PARP Drugs Help BRCA Ovarian Cancer Patients Live Longer
This meta-analysis of 12 studies evaluated PARP inhibitor–based therapy in patients with BRCA-mutated ovarian cancer. Results showed a signi…
Women with BRCA-mutated ovarian cancer gain real survival time gains when using PARP inhibitors to delay cancer growth and stay cancer-free …