Giant mesenteric fibromatosis progresses despite targeted therapy and immunotherapy in case report
One patient with a giant tumor progressed despite targeted therapy and immunotherapy
This review of a case report describes a patient with giant abdominal mesenteric fibromatosis who progressed rapidly despite targeted therap…
A single patient with a massive abdominal tumor saw it grow quickly even after receiving advanced drugs, followed by complex surgery.
Molecular markers may improve risk assessment in oral potentially malignant disorders
Molecular tools may improve risk assessment for oral lesions
This narrative review examines the limitations of conventional histopathological grading for oral potentially malignant disorders (OPMDs) an…
A review suggests molecular methods could better assess risk for oral potentially malignant disorders where standard grading is unreliable.
Vaginal irrigation self-management shows conditional support for cervical cancer patients undergoing radiotherapy
Vaginal irrigation helps cervical cancer patients on radiotherapy
This systematic review evaluates vaginal irrigation self-management in patients undergoing radiotherapy for cervical cancer. The analysis in…
A review of 23 trials suggests vaginal irrigation self-care may reduce complications for cervical cancer patients undergoing radiotherapy.
TIL therapy and engineered viral vector immunotherapies show pooled ORR of 37.8% in advanced melanoma
First new analysis in years shows TIL therapy response rates for advanced melanoma
This Bayesian meta-analysis synthesizes data from 13 eligible studies on TIL therapy and engineered viral vector immunotherapies for advance…
A Bayesian meta-analysis of 13 studies finds TIL therapy yields a 49% response rate in advanced melanoma, with moderate certainty for respon…
IL-17-targeted intervention implications for tissue injury remain uncertain due to lack of holistic regulatory perspective
New review explains how IL-17 works differently in injured tissues
This narrative review examines IL-17-targeted interventions for tissue injury. The authors note that the field lacks a holistic perspective …
A new review explains how IL-17 behaves differently in injured tissues, offering fresh ideas for tailored treatment strategies.
Adding docetaxel to ADT and RT cuts mortality in high-risk prostate cancer with normal testosterone
Adding chemo to hormone therapy for prostate cancer may depend on testosterone levels
This RCT subgroup analysis found that adding docetaxel to radiation and ADT significantly reduced all-cause mortality in nonmetastatic high-…
Adding chemo to standard therapy for high-risk prostate cancer may only help men with normal testosterone levels, a long-term study suggests…
T cell-based therapies show promise but face barriers in solid tumors
CAR-T and TIL therapies face hurdles in treating solid tumors
This narrative review examines CAR-T, TIL, and TCE therapies for hematologic and solid malignancies. Key challenges include on-target/off-tu…
A review notes that CAR-T, TIL, and TCE therapies struggle with tumor microenvironments and manufacturing issues for solid cancers.
Nivolumab monotherapy yielded 12-month progression-free survival in metastatic anaplastic thyroid cancer
Off-label immunotherapy may help some patients with metastatic anaplastic thyroid cancer
This case report describes a 76-year-old female with metastatic anaplastic thyroid cancer treated with off-label nivolumab monotherapy. The …
A single case report suggests off-label nivolumab helped a 76-year-old woman live longer with metastatic anaplastic thyroid cancer.
Favorable adiposity, statins, vitamin D, dried fruit linked to lower ovarian cancer risk in MR meta-analysis
Genetic study links vitamin D, statins to lower ovarian cancer risk
This systematic review and meta-analysis of Mendelian randomization studies found that genetically predicted favorable adiposity, HMG-CoA re…
Genetic evidence suggests vitamin D, statins, and dried fruit may lower ovarian cancer risk, but don't change treatment yet.
Digital health tools may ease anxiety and depression in colorectal cancer patients
Digital health tools may ease anxiety and depression in colorectal cancer patients
A meta-analysis of 2018 CRC patients suggests digital health interventions can reduce anxiety and depression while improving quality of life…
A review of 2,018 colorectal cancer patients suggests digital health tools can reduce anxiety and depression and improve quality of life, th…
Attenuated R-THP-COP regimen achieved complete response in an 85-year-old with diffuse large B-cell lymphoma
Attenuated R-THP-COP regimen shows promise for elderly diffuse large B-cell lymphoma
This case report describes an 85-year-old female patient with diffuse large B-cell lymphoma treated with an attenuated R-THP-COP regimen. Th…
An 85-year-old woman achieved complete radiological response and remained symptom-free for three years on an attenuated chemotherapy regimen…
Nature-based IVR reduces anxiety and distress in breast cancer patients with low certainty evidence
Nature-based virtual reality may ease anxiety and distress for breast cancer patients
This systematic review and meta-analysis evaluated nature-based immersive virtual reality (IVR) for breast cancer patients. The pooled analy…
A new analysis suggests nature-based virtual reality could help reduce anxiety and distress in breast cancer patients, offering a new tool f…