Ibrutinib monotherapy showed durable progression-free survival in patients with TP53 aberrations or advanced age
Ten Years on One Pill: What Long-Term Ibrutinib Revealed
This investigator-sponsored phase 2 study evaluated single-agent ibrutinib in 84 patients with chronic lymphocytic leukemia (CLL) harboring …
A decade of follow-up shows a daily pill can give high-risk leukemia patients years of control, but staying on it is not easy.
Phase 3 trial compares IMPT versus IMRT plus cisplatin in locally advanced oropharyngeal squamous cell carcinoma
The Pricier Radiation Did Not Beat Standard Radiation for Throat Cancer
This Phase 3 randomized controlled trial enrolled 205 patients with locally advanced oropharyngeal squamous cell carcinoma across 20 UK NHS …
A large UK trial found that precision proton radiation gave similar results to standard X-ray radiation, meaning the older treatment remains…
Neoadjuvant CAPOX chemotherapy alone showed comparable survival to chemoradiotherapy in locally advanced rectal cancer with uninvolved mesorectal fascia
Some Rectal Cancer Patients May Skip Radiation Without Losing Ground
This Phase III RCT compared 4 cycles of CAPOX chemotherapy alone versus chemoradiotherapy in patients with locally advanced rectal cancer an…
Some rectal cancer patients can skip pre-surgery radiation and still achieve similar cure rates while avoiding long-term side effects like b…
Talazoparib monotherapy in neoadjuvant triple-negative breast cancer reveals BRN2-driven resistance mechanisms
Why Some BRCA Breast Cancers Shrug Off Talazoparib Before Surgery
This Phase II neoadjuvant trial evaluated talazoparib in patients with germline mutant breast tumors.
Some BRCA breast cancers shrink under talazoparib, but others find hidden escape routes that let them ignore the drug before surgery.
In UK primary care, the NAT-C tool guided consultations resulted in clinical action for 72% of cancer consultations
Why a Simple Cancer-Care Tool Works in Theory but Stalls in Real GP Offices
This mixed-methods process evaluation examined the implementation of the Needs Assessment Tool-Cancer (NAT-C) in 21 UK general practices ser…
A simple cancer needs-assessment tool triggers action in 7 out of 10 doctor visits, but long-term success depends on local support and resou…
Itacitinib plus standard therapy in acute leukemia or myelofibrosis patients undergoing reduced-intensity conditioning donor stem cell transplantation
Early trial explores itacitinib for stem cell transplant patients with blood disorders
This Phase IIa trial evaluated itacitinib combined with tacrolimus and sirolimus in patients with acute leukemia, myelodysplastic syndrome, …
A new trial adds itacitinib to standard care for stem cell transplant patients with blood disorders to help prevent graft-versus-host diseas…
Higher dietary phytochemical index associated with better sleep quality in adults with type 2 diabetes
Plant-Rich Plates Linked to Better Sleep for Diabetics
A cross-sectional study of 675 adults with type 2 diabetes found that higher dietary phytochemical index (DPI) scores were associated with b…
A diet rich in plant-based foods tracked with longer sleep and lower inflammation in adults with type 2 diabetes.
Meta-analysis of 12 studies reports chemotherapy-induced nausea and vomiting prevalence and risk factors in breast cancer patients
Nearly Half of Breast Cancer Patients Face This Rough Side Effect
This meta-analysis pooled data from 12 studies involving breast cancer patients undergoing chemotherapy to assess the prevalence of chemothe…
Knowing who is most likely to get sick from chemo allows doctors to step in before nausea takes over a patient's life.
Electronic antiemetic device plus ondansetron improved delayed CINV response in 126 cancer patients
A Wearable Buzz on Your Wrist May Ease Chemo Nausea
This single-centre randomized controlled trial enrolled 126 cancer patients receiving moderately or highly emetogenic chemotherapy.
A small device targeting an old acupressure point may give real relief from the days-long nausea that chemo drugs leave behind.
Meta-analysis of 50 studies shows indeterminate chronic hepatitis B affects 39% of patients with elevated HCC risk
Four in Ten Hepatitis B Patients Live in a Medical Gray Zone
This systematic review and meta-analysis pooled data from 50 studies involving patients with chronic hepatitis B classified as indeterminate…
A huge share of hepatitis B patients sit in limbo between guidelines, and a new analysis shows that limbo is not as safe as it sounds.
Gradient warning nursing procedure reduced pressure ulcers in prone orthopedic surgery patients
New Nursing Method Cuts Bed Sores in Half
This retrospective cohort study evaluated 126 prone-positioned orthopedic surgery patients comparing a gradient warning nursing procedure (G…
A new nursing warning system slashes bed sore rates by 89% for spine surgery patients lying on their stomachs.
Late Wilms tumor recurrence observed 32 years after diagnosis in a single case report
A Childhood Kidney Tumor Returned 32 Years Later
This systematic review analyzed a case report of a one-year-old female with bilateral, favorable-histology Wilms tumor.
Very late recurrence of childhood kidney cancer is extremely rare but possible, and this case reminds survivors and doctors that long-ago ca…