PARP inhibitors significantly improve progression-free survival in BRCA-mutated ovarian cancer patients
PARP Drugs Help BRCA Ovarian Cancer Patients Live Longer
This meta-analysis of 12 studies evaluated PARP inhibitor–based therapy in patients with BRCA-mutated ovarian cancer.
Women with BRCA-mutated ovarian cancer gain real survival time gains when using PARP inhibitors to delay cancer growth and stay cancer-free …
Retrospective cohort study of 217 surgically treated borderline ovarian tumors in Southern Sweden compares conservative versus complete staging surgery
A Gentler Surgery for Ovarian Tumors May Be Safer Than We Thought
This retrospective, population-based cohort review evaluated 217 patients with borderline ovarian tumors (BOT) in Southern Sweden.
A less invasive surgery for borderline ovarian tumors may be just as safe as the standard approach, offering fewer complications without har…
Multimodal nomogram predicts axillary pathological complete response in node-positive breast cancer patients
Can scans stop unnecessary breast surgery?
This retrospective cohort study evaluated a multimodal nomogram combining ultrasonography, MRI, and clinicopathological features in 600 pati…
A new scan mix predicts if breast cancer is truly gone before surgery, helping doctors avoid unnecessary removal of lymph nodes and lifelong…
Phase 1 trial of off-the-shelf NK cell therapy shows no DLTs or responses in relapsed/refractory AML
A Safer, Ready-to-Use Cell Therapy Takes Aim at Tough Leukemia
A single-arm, open-label, dose-escalation Phase 1 trial enrolled 6 adults with relapsed/refractory AML who received SAR445419, an off-the-sh…
A new, ready-to-use cell therapy proved safe in a first human trial for aggressive leukemia, offering hope for patients who have run out of …
In Appalachian lung cancer patients, definitive chemoradiotherapy was associated with a 59% incidence of cardiovascular adverse events
A Simple Heart Scan Could Predict Your Biggest Risk During Lung Cancer Treatment
This retrospective cohort study evaluated 86 Appalachian patients with lung cancer treated with definitive chemoradiotherapy at a single ins…
For many battling lung cancer, the treatment meant to save them can quietly damage their heart, and a new analysis shows who is most in dang…
Concurrent TP53 and KRAS alterations show inconsistent survival impact across gastrointestinal cancers
Two Bad Genes Mean Different Things
A database analysis of multi-cancer cohorts found that concurrent TP53 and KRAS alterations were associated with significantly shorter overa…
Having two common cancer gene changes usually signals a worse outcome, but in stomach cancer, this same genetic mix actually predicts the lo…
Mitoxantrone liposome plus CMOP shows high response rates in untreated peripheral T-cell lymphoma patients
New Drug Combo Helps Most Patients With Hard-to-Treat Lymphoma
This phase 1b multicenter clinical trial evaluated mitoxantrone hydrochloride liposome combined with cyclophosphamide, vincristine, and pred…
A new drug combo wrapped in fat bubbles helped 89% of patients with hard-to-treat lymphoma shrink tumors without causing deaths.
Phase 1/2 trial shows RT + bevacizumab + olaptesed pegol extends PFS and OS in unmethylated GBM
New Drug Combo Slows Brain Cancer Growth
A Phase 1/2 expansion arm in six patients with newly-diagnosed, unmethylated GBM found that adding bevacizumab to radiotherapy and olaptesed…
Adding a second drug to stop blood vessel growth gives patients with brain cancer more time before the disease returns.
Meta-analysis shows radiomics-based machine learning models predict recurrence risk in non-small cell lung cancer patients
Your Lung Cancer Scan May Already Hold a Hidden Clue About Its Return
This systematic review and meta-analysis evaluated radiomics-based machine learning models for predicting recurrence risk in 7,964 patients …
Artificial intelligence can find hidden patterns in routine lung scans to predict if common lung cancer will return, giving patients a cruci…
MRLN sparing radiotherapy shows non-inferior survival, reduced toxicity in nasopharyngeal carcinoma
New Radiation Plan Saves Swallowing Power
A phase 3 RCT of 568 adults with untreated, non-metastatic nasopharyngeal carcinoma found MRLN sparing radiotherapy was non-inferior to stan…
A new radiation plan for throat cancer lets patients skip a specific area, helping them keep their swallowing strength and eat normally for …
Systematic review finds serum biomarkers show variable diagnostic accuracy for oral cancer detection
Blood Tests Could Spot Oral Cancer Sooner
A systematic review and meta-analysis of 3,309 subjects (2,069 with oral squamous cell carcinoma, 1,240 controls) examined multiple serum bi…
New blood tests using specific proteins could detect oral cancer before a visible lump forms, potentially saving lives through earlier diagn…
Serum triglyceride levels show no relationship with prostate cancer risk in a meta-analysis of Chinese men
High Triglycerides Do Not Raise Prostate Cancer Risk in Chinese Men
This meta-analysis evaluated the association between serum triglyceride levels and prostate cancer risk among 4,732 Chinese men.
High triglycerides do not increase prostate cancer risk in Chinese men, challenging earlier Western-based assumptions.