Nicotinamide Riboside Plus Exercise Improves Fitness in Friedreich's Ataxia
Combining exercise and nicotinamide riboside improved fitness in Friedreich's ataxia patients.
This phase 2 randomized trial in 66 individuals with Friedreich's ataxia found that 12 weeks of nicotinamide riboside plus exercise increase…
A 12-week trial found that combining exercise with nicotinamide riboside improved heart and lung fitness in people with Friedreich's ataxia.
Systematic review and meta-analysis of canonical babbling ratio trajectories in infants aged 5 to 24 months across 42 studies
Babbling grows steadily from five to twenty-four months in babies everywhere
This systematic review and meta-analysis examined canonical babbling ratio (CBR) measurement across 42 studies involving 1277 infants aged 5…
A large review found that babies babble more as they age, with interactive play sessions capturing more sounds than quiet home recordings.
Meta-analysis shows moderate positive learning effects from physically embodied educational robots in classrooms
Classroom Robots Boost Children's Learning, Review Finds
This meta-analysis reviews evidence on the impact of physically embodied educational robots (PERs) on learning outcomes in children. Analysi…
A review of 3665 children finds that physically embodied educational robots moderately improve learning outcomes.
Systematic review meta-analysis shows higher complication rates in young children undergoing tonsillectomy
Young kids under three can safely go home after tonsil surgery
This systematic review and meta-analysis evaluated complications of tonsillectomy or adenotonsillectomy in children aged 2 to 3 years compar…
New research shows toddlers aged two to three can likely go home the same day after having their tonsils removed without extra risk.
Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis
Combination therapy reduces relapse risk in children with eye inflammation from arthritis
This systematic review and meta-analysis of RCTs evaluated adalimumab plus methotrexate in children with juvenile idiopathic arthritis-assoc…
Combining adalimumab with methotrexate lowers relapse risk and helps reduce steroid use in children with arthritis-related eye inflammation.
Meta-analysis shows Mycoplasma pneumoniae prevalence in children varied before, during, and after COVID-19
Mycoplasma pneumoniae infections in children rose sharply after the pandemic ended
This systematic review and meta-analysis of 70 studies examined M. pneumoniae infection prevalence in children and adolescents before, durin…
A review of 70 studies shows infection rates in kids jumped significantly after the pandemic, while rates stayed low during the outbreak.
Meta-analysis shows integrated nursing interventions improve outcomes in paediatric severe pneumonia
Integrated nursing care improves severe pneumonia in children
This meta-analysis reviews six studies conducted in paediatric intensive care units involving paediatric patients with severe pneumonia. The…
A review of six studies finds that integrated nursing care helps children with severe pneumonia recover faster, with less fever and shorter …
Combined low-level laser and ultrasound therapy showed possible efficacy and safety for growing pains in children over 30 days.
New therapy may ease growing pains without using medicine
This pilot randomized controlled trial evaluated combined low-level laser and ultrasound therapy versus placebo in children aged four to twe…
A new treatment using light and sound waves could help children stop hurting without taking pills
Six H5N1 vaccine formulations showed immunogenicity and acceptable safety in 420 healthy children aged 6 months to 9 years.
Higher adjuvant content boosts immunity in children without added safety risks
This phase 2, observer-blind, multicenter study evaluated six formulations of MF59-adjuvanted H5N1 vaccine in 420 healthy infants and childr…
A Phase 2 trial in healthy children found that higher adjuvant content improved immune responses to an H5N1 vaccine without increasing side …
Valganciclovir dosing in congenital cytomegalovirus infection shows extensive drug accumulation in dried blood spots
New blood test tracks cCMV drug levels in infants
This randomized, placebo-controlled clinical trial (ValEAR) or open-label PK study evaluated infants with congenital cytomegalovirus infecti…
A new blood spot test helps doctors track cCMV medicine levels in babies to prevent dangerous side effects during treatment.
High-dose rifampicin pharmacokinetics differ across sites in tuberculosis infection randomized trial
High-dose rifampicin shows different drug levels in adults across three countries
This randomized controlled trial evaluated adults and adolescents aged ≥ 10 years with tuberculosis infection. Bioavailability was lower in …
Drug levels of high-dose rifampicin varied by country, with lower bioavailability seen in Canada and Vietnam compared to Indonesia in this t…
Vitamin A Supplementation at Birth Alters Vaccine Immune Responses Without Improving Antibody Levels in Infants
Vitamin A given at birth changes how babies respond to vaccines
This randomized, placebo-controlled trial enrolled 306 infants in Dhaka, Bangladesh receiving 50,000 IU Vitamin A within 48 hours of birth c…
A single vitamin A dose at birth may strengthen some vaccine responses in infants, but results vary by sex and vaccine type.