People with Friedreich's ataxia often struggle with heart and lung weakness. This trial tested whether adding a specific vitamin-like supplement called nicotinamide riboside to a regular exercise plan could help. Seventy-four individuals aged 10 to 40 years joined the study at the Children's Hospital of Philadelphia. They had a healthy heart pumping ability and could exercise safely.
The group took either the supplement or a placebo while doing personalized workouts. Some took the supplement without exercise, while others exercised without the supplement. The main goal was to measure how much their peak oxygen use improved after 12 weeks.
The combination of nicotinamide riboside and exercise showed the best results. Participants in this group gained more fitness than those who did only one or the other. The treatment was safe, with only mild side effects like stomach issues or skin rashes. No serious problems occurred.
However, the study was short. Researchers say longer trials are needed to know if this mix could become a standard long-term treatment. This trial offers hope but more time is required to confirm its lasting benefits.