Systematic review and meta-analysis of levetiracetam efficacy in pediatric epilepsy patients
Levetiracetam shows seizure benefits over placebo in children with epilepsy
This systematic review and meta-analysis evaluated levetiracetam (LEV) in patients 16 years or younger with epilepsy. The analysis included …
A large analysis found levetiracetam improved seizure freedom and responder rates compared to placebo in children, though it did not consist…
Narrative review highlights distinct biological processes in pediatric suicidal behavior compared to adults
Biological markers of youth suicide differ from adults
This narrative review examines biological signatures of suicidal ideation, suicide attempts, and death by suicide in pediatric and adolescen…
A review suggests biological signs of suicidal thoughts in children and teens are distinct from adults, meaning adult data cannot explain yo…
Review of ruxolitinib for systemic juvenile arthritis with macrophage activation syndrome
Two children with severe arthritis found relief using a new drug approach
This narrative review synthesizes a retrospective case series and literature search on ruxolitinib for systemic juvenile idiopathic arthriti…
Two children with severe arthritis complications found relief using a new drug approach, offering hope for those who struggle with standard …
Case report describes bilateral simple excision in a 10-year-old child with cervical branchial remnants
Simple surgery removed rare neck growths in a 10-year-old child
This publication is a case report and review of the literature describing a 10-year-old child with bilateral cervical chondrocutaneous branc…
A 10-year-old child with rare neck growths had them removed with simple surgery, showing no safety concerns in this single case report.
Achievement emotions and working memory correlate with second language learning in primary school students
Emotions and relationships matter for young students learning a second language
This systematic review and meta-analysis evaluated 19 primary studies involving 5,340 participants to examine factors influencing second lan…
A large review shows how feelings like anxiety and closeness to teachers directly impact how well primary school students learn a second lan…
GSK investigational MMRV vaccine shows comparable immunogenicity to licensed MMRV in healthy children
GSK MMRV vaccine shows comparable safety and immune response to licensed MMRV in young children
This randomized, multi-country phase II trial in 801 healthy children aged 4-6 years found that one dose of a GSK investigational MMRV vacci…
A Phase II trial in healthy children found the investigational GSK MMRV vaccine produced immune responses and safety similar to the licensed…
Case report confirms X-linked Alport syndrome diagnosis in a young girl with family history
Early testing confirms X-linked Alport syndrome in a toddler
This case report describes a 4-year-2-month-old girl with X-linked Alport syndrome who underwent renal biopsy and genetic testing. The diagn…
A young girl with a family history of kidney disease received a quick diagnosis through biopsy and genetic tests.
Systematic review of orthognathic surgery outcomes in 6,482 patients with dentofacial deformities
Orthognathic surgery improves jaw alignment and quality of life for thousands of patients
This systematic review and meta-analysis evaluated clinical outcomes for orthognathic surgery in 6,482 patients with dentofacial deformities…
A large review of over 6,000 patients shows orthognathic surgery improves jaw alignment and quality of life, with most nerve issues resolvin…
Meta-analysis shows early kangaroo care reduces mortality in very preterm infants compared to conventional care
Early skin-to-skin contact may lower death risk for very preterm babies
This systematic review and meta-analysis evaluated early kangaroo care versus conventional neonatal care in very preterm infants (≤32 weeks)…
A review of trials found that starting skin-to-skin care within 24 hours reduced death risk for very preterm infants, though effects on infe…
Narrative review of Digital First Primary Care model in NHS England patients
Digital-first care offers flexibility but gains are uneven for NHS patients
This narrative review evaluates the Digital First Primary Care (DFPC) model for patients in NHS England. The authors synthesize evidence reg…
A review of NHS England data shows digital-first care can improve convenience and timeliness for some patients, though benefits are not shar…
Guideline secondary analysis shows non-significant trend for higher enteral nutrition use in pediatric Crohn's disease registry groups
Registry tool shows mixed results for pediatric Crohn's nutrition
This guideline secondary analysis of a cluster-randomized trial examines enteral nutrition patterns in 110 children with Crohn's disease. Th…
A new registry tool did not significantly boost enteral nutrition use in children with Crohn's, but it may lower steroid use in the first 90…
Narrative review discusses paradoxical inflammatory reactions in pediatric patients receiving biologic therapy
Biologic therapy may cause paradoxical inflammation in children
This narrative review examines paradoxical inflammatory reactions in pediatric patients receiving biologic therapy. The authors note that a …
A review notes that biologic therapy can trigger paradoxical inflammatory reactions in pediatric patients, highlighting a need for careful m…