Co-design workshops with families improved study tools for rare genetic and neurodevelopmental conditions.
Sleep study designed by families, not just doctors
This public involvement study engaged nine parents and 13 young people with neurodevelopmental conditions caused by copy number variants. Co…
Working side-by-side with parents made a sleep study for rare genetic conditions fairer and easier to join.
Chronic pain linked to 7.5-fold increase in severe depressive symptoms in UK Biobank analysis
Does chronic pain make depression worse? New data says yes, and the link goes both ways.
An observational study of 142,688 UK Biobank participants found chronic pain associated with a 7.50-fold increase in severe depressive sympt…
Chronic pain makes depression worse and depression increases pain risk, creating a two-way link that affects mood, focus, and appetite.
Criminal legal involvement correlates with baseline symptoms and substance use in US first-episode psychosis patients.
Early psychosis care may lower the risk of arrest
This secondary analysis of a cluster randomized controlled trial examined criminal legal involvement (CLI) in 381 US patients with first-epi…
When psychosis is caught and treated sooner, people are less likely to end up tangled in the legal system during recovery.
Group-based TSC intervention mediates improvements in depression and anxiety via insomnia severity in adults with MDD.
Did fixing sleep actually help depression, or was it just how patients felt about their rest?
This secondary analysis of a randomized controlled trial examined 152 adults with major depressive disorder receiving a group-based Transdia…
Feeling like sleep improved drove the real gains in depression and anxiety, proving that how patients perceive their rest matters more than …
Seltorexant vs Quetiapine-XR for MDD: Similar Discontinuation, Numeric MADRS Benefit at Lower Dose
New Drug Helps Depression When Sleep Is Lost
An exploratory phase 2 RCT compared adjunctive seltorexant (20/40 mg) to quetiapine-XR (150/300 mg) in SSRI/SNRI-inadequate responders with …
A new sleep drug helps lift depression without the weight gain or dizziness often caused by older treatments for patients who struggle to re…
Letrozole protocol associated with higher live birth and lower adverse outcomes versus estrogen-progesterone in ovulation disorder FET
Letrozole Prep Boosts Live Births, Lowers Risks
This single-center retrospective cohort study compared ovulation induction using Letrozole against an artificial programmed protocol using e…
Women with ovulation issues who take Letrozole before frozen embryo transfers have higher live birth rates and lower risks of miscarriage an…
Cohort study of 910 Chinese nurses links mental health, night shifts to metabolic disease trajectories
For nurses, what matters more for metabolic health: diet or mental strain?
A 2018-2022 cohort study of 910 Chinese nurses identified three metabolic disease trajectories. Compared to a Maintaining-Low group, lack of…
For nurses starting healthy, rising anxiety and night shifts—not bad diets—linked to worsening metabolic health like diabetes or high blood …
Phase 2 RCT finds AI-coached therapy improves depression and anxiety symptoms versus waitlist
AI Voice Coach Beats Waiting for Depression Help
A phase 2 RCT of 200 adults with depression/anxiety compared AI-coached problem-solving therapy (PST) via Alexa to human-coached PST and a w…
A voice-based AI coach matched human therapists in helping adults with depression and anxiety improve their mood and daily life after 18 wee…
Digital health technologies improve malaria vaccine adherence and data quality in African populations.
Your Phone Could Be the Key to Ending Malaria in Africa
This systematic review evaluated digital health (DH) and mobile computing (mHealth) technologies in African populations. Interventions inclu…
Simple text messages and voice calls could be the missing piece to ensure new malaria vaccines protect the children who need them most.
Case-control study finds higher anti-GAD antibodies in children with autism spectrum disorder
A Simple Blood Test May Reveal a Hidden Clue in Autism
A clinic-based case-control study of 90 children (45 with ASD, 45 controls) found higher anti-GAD antibody levels in the ASD group (p=0.003)…
Higher levels of a specific antibody in the blood are linked to autism symptom severity and the loss of skills in young children.
Cross-sectional study finds brain structure alterations in chronic pain and depression
Pain and Sadness Share a Unique Brain Map
A cross-sectional observational study of 71,214 UK Biobank participants found widespread brain structure alterations in individuals with com…
Millions with chronic pain and depression have a unique brain map that differs from having just one condition, changing how doctors should t…
Narrative synthesis reviews bidirectional links between diabetes and mental disorders.
Diabetes and Mental Health: Breaking the Cycle Together
This narrative synthesis examined epidemiological evidence, bidirectional mechanisms, and integrated management models for diabetes and ment…
High blood sugar changes brain chemistry while stress raises blood sugar, creating a tough cycle that makes managing diabetes and mental hea…