AI CBT chatbot access reduces anxiety and depression symptoms in Brazilian primary care patients
Could a chatbot ease anxiety for patients near a specific care threshold?
A quasi-experimental study of 43,287 primary care patients in Brazil found that access to an AI-powered CBT chatbot causally reduced PHQ-ADS…
Patients near a care threshold who used an AI chatbot saw real improvements in anxiety and depression over 12 weeks in Brazil.
Medication-free major depressive disorder associated with age-dependent accelerated structural brain aging compared to healthy controls
Medication-free depression linked to accelerated brain aging in older adults
This observational cross-sectional MRI analysis compared medication-free individuals with major depressive disorder in a current episode to …
Depression in older adults without medication shows accelerated brain aging, with the gap widening to nearly seven years by age 55.
Adolescent inpatients with suicidal thoughts show increased risk-taking in decision-making task
Do risky choices in teens predict suicidal thoughts, and what does this mean for prevention?
An observational study of 83 adolescent inpatients with affective disorders and 118 healthy controls found those with suicidal thoughts and …
Teens with suicidal thoughts crave risky rewards more than safe ones, a brain pattern that predicts how severe their feelings are and links …
Large language models show potential for psychosis risk assessment from clinical interview transcripts
AI language models show promise for assessing early psychosis risk from interviews
An evaluation study of 373 participants with clinical high risk for psychosis transcripts found that large language models (LLMs) achieved 8…
Large AI models correctly identified early psychosis risk 80% of the time from interview transcripts, matching human expert scores while mos…
Corticolimbic Glutamate-Functional Connectivity Associations Found in Antipsychotic-Naive CHR-P Individuals
Could early brain changes in psychosis risk be linked to specific chemical connections?
An observational study of antipsychotic-naive clinical high-risk for psychosis (CHR-P) participants (n=22), healthy controls (n=23), and fir…
People at high risk for psychosis show weaker brain chemical connections before symptoms appear, unlike those who have already developed the…
Children with SLD-R showed worse phonemic awareness than controls in Malayalam
Children with reading disorders showed weaker phonemic awareness skills in Malayalam compared to peers
This observational study compared phonemic awareness in 30 children with Specific Learning Disorder-Reading (SLD-R) and 29 typically develop…
Children with reading disorders struggled more with sound blending in Malayalam than peers, especially when guessing new words without pictu…
Qualitative interviews with 26 participants reveal a five-stage dynamic model of accepting anxiety
Researchers describe a five-stage model of how people accept anxiety through interviews
This qualitative study interviewed 26 non-clinical participants with prior mindfulness-based anxiety intervention experience to explore acce…
A new five-stage model shows how people learn to accept anxiety by observing bodily signals, validating feelings, and staying present withou…
Normative latent cognitive structure metrics delineate cognitive heterogeneity across schizophrenia liability spectrum in healthy controls, siblings, and patients
Study finds cognitive changes in schizophrenia siblings before clinical symptoms appear
This observational study evaluated cognitive heterogeneity using a normative latent cognitive structure (N-LCS) in healthy controls, unaffec…
Cognitive changes in reasoning and processing speed appear in schizophrenia siblings before clinical symptoms show, offering early warning s…
Autonomic arousal moderates network switching-cognition link in healthy controls but not schizophrenia
Does your brain's switching speed change with stress? New data suggests it might in schizophrenia
An observational study of 105 participants (39 healthy controls, 27 psychiatric controls, 39 with schizophrenia spectrum disorders) found au…
In people with schizophrenia, stress no longer affects how brain switching connects to thinking skills, unlike in healthy individuals.
Meta-analysis finds moderate negative correlation between meaning in life and depression
Large review finds link between sense of meaning in life and lower depression
A three-level meta-analysis of 278 studies (n=252,254) found meaning in life was moderately negatively correlated with depression (r = -0.33…
People with a stronger sense of meaning or purpose in life tend to report lower levels of depression, according to a large review of hundred…
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight.
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
MPNFS-based psychological intervention linked to reduced anxiety in adolescents with anxiety disorders
Psychological intervention shows promise for reducing anxiety in adolescents
A retrospective cohort study of 196 adolescents with anxiety disorders found that a 6-week MPNFS-based integrative psychological interventio…
Teenagers with anxiety disorders showed significantly greater improvement after a six-week psychological intervention compared to standard c…