IEN plus NACT shows greatest improvement in CD4+ counts among ranked strategies
New research identifies ways to protect immune cells during cancer surgery
This network meta-analysis of 82 RCTs evaluates multimodal interventions to maintain T lymphocyte subsets in patients with solid tumors unde…
A new analysis shows that combining specific nutrition and therapies can help maintain vital immune cell levels for patients undergoing soli…
Elevated serum M2BPGi is associated with a 4.61 hazard ratio for hepatocellular carcinoma development
Elevated M2BPGi Levels Linked to Higher Risk of Liver Cancer
This systematic review and meta-analysis of 12,161 participants found that elevated serum M2BPGi is significantly associated with an increas…
A large review of over 12,000 patients found that high levels of a specific protein may signal an increased risk for liver cancer.
Combination therapies with adalimumab, infliximab, tofacitinib, or upadacitinib increase serious infection risk in rheumatoid arthritis
New data shows infection risks for rheumatoid arthritis treatments
This meta-analysis of 55,749 patients with rheumatoid arthritis found that while b/tsDMARD monotherapy carries a similar risk of serious inf…
New research highlights how combining certain medications for rheumatoid arthritis can increase the risk of serious infections.
Integrated simulation-based training models provide a framework for perioperative point-of-care ultrasound competency
New training models improve ultrasound skills for surgical team members
This narrative review explores various simulation-based education models and assessment strategies for perioperative point-of-care ultrasoun…
Medical teams can move from theory to safe bedside practice using six different simulation-based training models for point-of-care ultrasoun…
Opsin 3 serves as a potential therapeutic target for melanoma and inflammatory skin diseases
Opsin 3 May Offer New Path for Skin Disease Treatment
This narrative review explores the role of Opsin 3 (OPN3) in skin pathophysiology, including its involvement in UV damage, melanoma developm…
A protein called Opsin 3 may play a key role in how skin cells respond to UV damage, aging, and inflammation.
EMG biofeedback assisted pelvic floor training improves muscle strength and reduces incontinence severity
Biofeedback training shows some benefits for stress urinary incontinence
This meta-analysis of 1,045 women with stress urinary incontinence found that EMG-BF supported PFMT leads to a small reduction in incontinen…
Adding biofeedback to pelvic floor exercises may improve muscle strength and quality of life for women dealing with stress urinary incontine…
Extracellular vesicles offer immunomodulatory mechanisms and targeted delivery for potential precision therapies in rheumatoid arthritis
Tiny cell particles may offer new way to treat rheumatoid arthritis
This systematic review examines the role of extracellular vesicles, including exosomes and microvesicles, as vehicles for immunomodulation a…
Scientists are exploring tiny cell particles called extracellular vesicles as a potential new treatment for rheumatoid arthritis, but challe…
Comprehensive clinical reference system integrates etiology, diagnosis, and management for chronic pancreatitis complications
New Clinical Reference System for Managing Chronic Pancreatitis Complications
This narrative review synthesizes the etiology, diagnostic criteria, and management strategies for primary complications of chronic pancreat…
A new clinical reference system helps doctors identify and manage common complications like digestive issues and bone disease in patients wi…
Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies
Gut health may play a role in osteoarthritis joint pain
This narrative review synthesizes evidence linking gut microbiota dysbiosis to osteoarthritis. Human studies show OA-associated changes in m…
New research suggests that imbalances in gut bacteria could contribute to cartilage damage and inflammation in people with osteoarthritis.
Intestinal subepithelial myofibroblasts drive mucosal repair and pathological fibrosis in Inflammatory Bowel Disease
New Research Identifies Key Cells Driving Fibrosis in Inflammatory Bowel Disease
This narrative review explores the role of intestinal subepithelial myofibroblasts (ISEMFs) as central regulators of epithelial homeostasis …
Researchers have identified specific cells in the gut that drive scarring and tissue damage in people with inflammatory bowel disease.
FDA Approves Xeljanz XR (tofacitinib) for Multiple Inflammatory Conditions
FDA approves new arthritis and colitis drug Xeljanz XR for adults and children.
The FDA approved Xeljanz XR (tofacitinib) extended-release tablets for adult patients with moderately to severely active rheumatoid arthriti…
The FDA approved Xeljanz XR (tofacitinib) for adults with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative …
FDA Approves Xeljanz (tofacitinib) for Multiple Inflammatory Conditions
FDA approves new oral drug Xeljanz for arthritis and colitis.
The FDA approved Xeljanz (tofacitinib) tablets and Xeljanz XR extended-release tablets for adults with moderately to severely active rheumat…
The FDA approved Xeljanz (tofacitinib) for adults with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative col…